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Virginia Commonwealth University
Internal Medicine Publications
BONE-MINERAL DENSITY; HORMONE REPLACEMENT THERAPY; FRACTURE INTERVENTION TRIAL; VERTEBRAL FRACTURES; AMINOBISPHOSPHONATE ALENDRONATE; ANTIRESORPTIVE AGENTS; RANDOMIZED-TRIAL; ORAL ALENDRONATE; ELDERLY-WOMEN; HIP FRACTURE
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Full-Text Articles in Medicine and Health Sciences
Ten Years’ Experience With Alendronate For Osteoporosis In Postmenopausal Women, Henry G. Bone, David Hosking, Jean-Pierre Devogelaer, Joseph R. Tucci, Ronald D. Emkey, Richard P. Tornino, Jose A. Rodriguez-Portales , M.D., Robert W. Downs, Jayanti Gupta, Arthur C. Santora, Uri A. Liberman
Ten Years’ Experience With Alendronate For Osteoporosis In Postmenopausal Women, Henry G. Bone, David Hosking, Jean-Pierre Devogelaer, Joseph R. Tucci, Ronald D. Emkey, Richard P. Tornino, Jose A. Rodriguez-Portales , M.D., Robert W. Downs, Jayanti Gupta, Arthur C. Santora, Uri A. Liberman
Internal Medicine Publications
Background
Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated with alendronate for up to 10 years.
Methods
The initial three-year phase of the study compared three daily doses of alendronate with placebo. Women in the original placebo group received alendronate in years 4 and 5 and then were discharged. Women in the original active-treatment groups continued to receive alendronate during the initial extension (years 4 and 5). In two further extensions (years 6 and 7, and 8 through 10), women who had …