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Virginia Commonwealth University
Graduate Medical Education (GME) Resident and Fellow Research Day Posters
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Cryptogenic New Onset Refractory Status Epilepticus (Norse) Responsive To Rituximab, Matthew David Anderson, Teryn Nogles, Soundarya Gowda
Cryptogenic New Onset Refractory Status Epilepticus (Norse) Responsive To Rituximab, Matthew David Anderson, Teryn Nogles, Soundarya Gowda
Graduate Medical Education (GME) Resident and Fellow Research Day Posters
Objective: Discuss a case of new onset refractory status epilepticus (NORSE) in an otherwise healthy adult that had a positive outcome and suggests considering immunomodulators as first line treatment.
Background: NORSE is diagnosed when refractory status patients have no known history of seizures and an unremarkable workup. Other than antiepileptics and anesthetic coma, there are currently no established guidelines for management. Typically, IV steroids, plasma exchange, and IVIG are first line treatments. When these fail, second line immunomodulators are considered. Deciding between these agents is often arbitrary, and no particular agent has demonstrated consistently positive results. Prognosis is poor with …