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Astrocyte Elevated Gene-1 (Aeg-1) Deletion Selectively Enhances The Antinociceptive Effects Of Morphine, Apurva Puli, Shivani Patel, Bryan Mckiver, Eda Köseli, Devanand Sarkar Ph.D., M. Imad Damaj Ph.D.
Astrocyte Elevated Gene-1 (Aeg-1) Deletion Selectively Enhances The Antinociceptive Effects Of Morphine, Apurva Puli, Shivani Patel, Bryan Mckiver, Eda Köseli, Devanand Sarkar Ph.D., M. Imad Damaj Ph.D.
Undergraduate Research Posters
Background: Opioids are a class of drugs that are utilized in clinical settings to alleviate acute and chronic pain, but can often lead to development of tolerance, addiction and overdose following prolonged usage. Opioids such as morphine function by activating endogenous µ opioid receptors, which are located in various tissues throughout the body. Astrocyte Elevated Gene-1 (AEG-1) is a multifunctional protein that regulates inflammation, myeloid cell activity and lipid metabolism. Studies have shown interactions and overlaps in cellular signaling between the inflammatory/immune responses and the endogenous opioid system which could suggest a role for AEG-1 in opioids effects. Our goal …