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Full-Text Articles in Medicine and Health Sciences
Understanding And Targeting The C-Terminal Binding Protein (Ctbp) Substrate-Binding Domain For Cancer Therapeutic Development, Benjamin L. Morris
Understanding And Targeting The C-Terminal Binding Protein (Ctbp) Substrate-Binding Domain For Cancer Therapeutic Development, Benjamin L. Morris
Theses and Dissertations
Cancer involves the dysregulated proliferation and growth of cells throughout the body. C-terminal binding proteins (CtBP) 1 and 2 are transcriptional co-regulators upregulated in several cancers, including breast, colorectal, and ovarian tumors. CtBPs drive oncogenic properties, including migration, invasion, proliferation, and survival, in part through repression of tumor suppressor genes. CtBPs encode an intrinsic dehydrogenase activity, utilizing intracellular NADH concentrations and the substrate 4-methylthio-2-oxobutyric acid (MTOB), to regulate the recruitment of transcriptional regulatory complexes. High levels of MTOB inhibit CtBP dehydrogenase function and induce cytotoxicity among cancer cells in a CtBP-dependent manner. While encouraging, a good therapeutic would utilize >100-fold …
The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier
The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier
Undergraduate Research Posters
Purpose: Abstract for poster submission to VCU Poster Symposium for
Undergraduate Research and Creativity
Title: The Metabolism of Alcohol: Risk and Protective Factors
Background: In 2002, it was reported by the National Institutes of Health that
60.3% of college aged students (18-22) drank alcohol in the past month of being
asked, as compared to 51.9% of those not in college. They also found that 20% of
college students met the criteria for at least one alcohol use disorder (AUDs)1.
Many genes have been linked to an increased risk for AUDs and how individuals
with various ethnic backgrounds respond to alcohol. …