Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Student Research Symposium
Declining body-wide levels of nicotinamide adenine dinucleotide (NAD) that are present in normal aging men are linked to decreased sperm quality and DNA integrity. When NAD is low, the amount of oxidative stress on the DNA appears to be increased, due to the limited regeneration of the antioxidant glutathione, which is NAD-dependent. We therefore hypothesize that the increased sperm DNA damage in the aging male is caused by an elevated formation of 8-oxoguanine in the DNA, caused by increased oxidative stress when NAD levels are low. To test this hypothesis, a transgenic mouse model (ANDY mouse) was used to create …
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Student Research Symposium
It has become a common trend for people to start their families at a later age, often due to lifestyle choices like achieving career goals first and waiting to achieve financial stability. Along with this trend of increasing parental age comes another, the decrease in fertility. While it is well established that female fertility declines significantly with age, current research is showing that male fertility may be impacted just as much. NAD (Nicotinamide Adenine Dinucleotide) is an important biochemical cofactor in most metabolic reactions, and importantly, is it also essential for DNA repair. As age increases in humans, the amount …