Medicine and Health Sciences Commons^™

Characterization Of Cytokine Induction And Effects Of Antiviral Treatment In Four Murine Models Of Poxvirus Infection, Corinna W. Knorr

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cytokine profiles during cowpox virus (CPV) strain Brighton and vaccinia virus (VV) strain Western Reserve infections were characterized in intranasal (i.n.) and intraperitoneal (i .p.) models in BALB/c mice. The time-course of induction and effects of cidofovir treatment on interferon (IFN)-γ, IFN-γ inducible protein (IP)-10, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 were determined. The four models have distinct patterns of cytokine induction. CPV i.p. and VV i.n. infections showed increased induction throughout the time studied. CPV i.n. infection resulted in delayed induction of IFN-γ and IP-10. Cytokine levels were fairly constant during VV i.p. infections. Cidofovir treatment (100 mg/kg/day …

Catabolism Of Amino Acids To Volatile Fatty Acids By Lactococcus Lactis, Balasubramanian Ganesan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lactic acid bacteria are essential as flavor producers of cheese and fermented products. They are capable of catabolizing aromatic, branched chain, and sulfur amino acids to flavor compounds. During cheese ripening the numbers of lactococcal colonies decrease, but lactococci survive without replication in culture. This prompted an investigation into possible mechanisms of catabolism of branched chain amino acids into branched chain fatty acids and the physiological relevance of amino acid catabolism to the bacteria. We hypothesized that lactococci catabolize branched chain amino acids to branched chain fatty acids during nonculturability.

Lactococci, lactobacilli, and brevibacteria catabolized both branched chain amino acids …