Medicine and Health Sciences Commons^™

Hematologic Effects Of Cryogenine And Certain Selected Anti-Inflammatory Agents, Stanley Teruo Omaye

University of the Pacific Theses and Dissertations

Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.

There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. …

Pharmacologic Investigation Of The Anti-Inflammatory Activity Of Cryogenine And Selected Benzoquinolizine Derivatives, Louis Decato

University of the Pacific Theses and Dissertations

It has become apparent in recent years that many centrally active agents possess potential anti-inflammatory capabilities. The central or peripheral mechanisms of action for these agents have not been delineated nor has their clinical efficacy baan established or refuted. The centrally active drugs, cryogenine and tetrabenazine (a benzoquinolizine derivative), previously have been shown in this laboratory to inhibit certain models of induced inflammation. The present study in rats verifies the anti-inflammatory properties of cryogenic and established that a structurally related series of benzoquinolizine derivatives possessed the capability of inhibiting both exudative (carrageenan-induced pedal edema) and proliferative (cotton pellet granuloma) models …