Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Pharmacy and Pharmaceutical Sciences (10)
- Medicinal and Pharmaceutical Chemistry (7)
- Chemistry (3)
- Medicinal-Pharmaceutical Chemistry (3)
- Physical Sciences and Mathematics (3)
-
- Social and Behavioral Sciences (3)
- Education (2)
- Life Sciences (2)
- Rehabilitation and Therapy (2)
- Sports Sciences (2)
- Sports Studies (2)
- Communication (1)
- Communication Sciences and Disorders (1)
- Dentistry (1)
- Exercise Science (1)
- Kinesiology (1)
- Medical Education (1)
- Medical Specialties (1)
- Mental and Social Health (1)
- Other Rehabilitation and Therapy (1)
- Speech Pathology and Audiology (1)
- Trauma (1)
- Keyword
-
- Pharmaceutical sciences (8)
- Chemistry (3)
- Health sciences (3)
- Pharmacology (2)
- AHR (1)
-
- Access to Dental Care (1)
- Anxiety (1)
- Aryl hydrocarbon receptor (1)
- BSA (1)
- Biologics (1)
- Cancer (1)
- Communication Competence (1)
- Dental Education (1)
- Dentistry (1)
- Depression (1)
- Developmental Disabilities (1)
- Dissociative Photoionization (1)
- Draft Order (1)
- EVCit (1)
- Education (1)
- Educational tests (1)
- Emotional Intelligence (1)
- Excipients (1)
- First responder spouses (1)
- Gastrointestinal Transit (1)
- Half-life (1)
- Hydrofluorocarbons (1)
- Intellectual Disabilities (1)
- Major League Baseball (1)
- Measurements (1)
Articles 1 - 17 of 17
Full-Text Articles in Medicine and Health Sciences
Aac Camp As A Pre- And Post- Service Training Model, Joanne Kim
Aac Camp As A Pre- And Post- Service Training Model, Joanne Kim
University of the Pacific Theses and Dissertations
The purpose of this study was to determine the effectiveness of participation in an AAC-based day camp as a pre-service training opportunity for students of speech-language pathology and a post-training opportunity for practicing speech-language pathologists (SLPs). Following the conclusion for the most recent iteration of the AAC Academy hosted by the Diagnostic Center of Central California, students and SLPs who volunteered within the past ten years were recruited via email to participate in semi-structured interviews. Upon thematic analysis of the interview transcripts, the following themes were conceptualized: (1) Many volunteers had some interest, if not experience, with AAC prior to …
Comparison Of First-Time Neurocognitive Baseline Cognigram Assessments Between American And Brazilian Professional Bull Riding Athletes, Peter Wang
University of the Pacific Theses and Dissertations
The purpose of this study was to compare the first-time neurocognitive concussion baseline outcomes, using the Cognigram assessment software, between American and Brazilian professional bull riders. The analysis was performed using the database provided by the Professional Bull Riding Association Sports Medicine staff. The Cognigram assessment measures and analyses four outcomes: Psychomotor Function, Attention, Learning, and Working Memory Speed. The study examined the test outcomes of 210 professional bull riders (150 American, 60 Brazilian). A one-way multivariate analysis of covariance (MANCOVA) was used to determine if there a significant difference in the four assessment outcomes when comparing the country of …
Depression And Anxiety Amongst College D1 Athletes, Jessica Radford
Depression And Anxiety Amongst College D1 Athletes, Jessica Radford
University of the Pacific Theses and Dissertations
College student-athletes are having an increasingly amount of mental health concerns recently at an alarming rate. Therefore, researchers should attempt to better understand how student-athletes can cope with their mental health problems to improve their mental and physical well-being. The researcher administered a questionnaire to 300 college students, 150 student-athletes and 150 non-athletes from the University of the Pacific using various modified scales examining emotional intelligence, depression, anxiety, coping strategies, intentions to seek help, self-stigma, public stigma, social network stigma, alcohol consumption, sleep deprivation, and communication competence. The data were analyzed to determine the severity of student-athletes’ mental health and …
The Vagabond Flourine Atom Revisited: Dissociative Photoionization Of Tri- And Pentafluoropropene, Jessica K. De La Cruz
The Vagabond Flourine Atom Revisited: Dissociative Photoionization Of Tri- And Pentafluoropropene, Jessica K. De La Cruz
University of the Pacific Theses and Dissertations
Photoelectron Photoion Coincidence (PEPICO) Spectroscopy studies on two unsaturated hydrofluorocarbons (HFCs), also known as hydrofluoroolefines (HFOs), are presented here. Previously, the Sztáray group has studied the dissociation of trans-1,3,3,3-tetrafluoroprop-1-ene (ElixClean), which is a fourth-generation refrigerant and propellant and has lower global warming potential than its precursors. My study is an extension of the ElixClean study as it aims to explore how the different number of fluorine atoms impact the dissociation reactions of these molecules. Both 3,3,3-trifluoropropene (TFP) and cis-1,2,3,3,3- pentafluoropropene (PFP) are also utilized as propellants and refrigerants.Measurements were carried out with remote access to the CRF-PEPICO (combustion reactions followed …
The Combinatory Effects Of Pediatric Obesity And Ontogeny On Monocarboxylate Transporter Expression In Tissues Of Drug Disposition, Michael Ng
University of the Pacific Theses and Dissertations
Proton-coupled and sodium-dependent monocarboxylate transporters are encoded by the SLC16A and SLC5A gene family of solute carriers, and are responsible for the transport of essential nutrients such as L-lactate, pyruvate, and ketone bodies. Basigin, or CD147, acts as an ancillary protein for MCT1 and MCT4, and is involved in membrane surface expression of transporters. MCT's are also involved in the shuttling of monocarboxylic xenobiotics across cell membranes, including the drugs valproate and gamma hydroxybutyrate. MCT’s are also important for normal mammalian development, particularly during embryogenesis and early neonatal life. Previous studies have shown that ketogenic diets increase MCT expression in …
Expression Of Mouse Full-Length Aryl Hydrocarbon Receptor And Human Aryl Hydrocarbon Receptor Ligand Binding Domain In Pichia Pastoris, Yiyuan Wang
University of the Pacific Theses and Dissertations
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates biological responses to planar aromatic hydrocarbon. AHR activates gene transcription by binding to its corresponding enhancer with its partner-aryl hydrocarbon receptor nuclear translocator (ARNT). In addition, this receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. AHR exists widely in body tissues and affects bioactivation of carcinogenic compounds, T cell differentiation, fatty acid synthesis, cell proliferation, hematopoietic stem cell differentiation, respiratory reactivity, and insulin sensitivity. Although the precise mechanism illustrating the endogenous AHR function remains unclear, there has been intense interest in exploring AHR as a …
Gc/Ms And Lc/Ms Approaches To Chemical Communication In Plants And Marine Cyanobacteria, Carolyn Keim
Gc/Ms And Lc/Ms Approaches To Chemical Communication In Plants And Marine Cyanobacteria, Carolyn Keim
University of the Pacific Theses and Dissertations
Natural products are small organic compounds synthesized by living organisms including plants, animals, and microbes. These fall into one of two categories, primary metabolites are required for survival, but secondary metabolites usually play a more accessory role. Extracts from organisms have proven to be useful to humans throughout history. Prior to evidence-based western medicine practices, natural products were the only source of medicine and remain as a treatment source for underdeveloped nations. Today, natural products have either been approved by or have served as the template for many FDA approved drugs. Based on a survey of all FDA approved drugs …
Effects Of Tommy John Surgery, Draft Order, And Monetary Factors On The Value Of Pitchers In Major League Baseball, Jonathan P. Wong
Effects Of Tommy John Surgery, Draft Order, And Monetary Factors On The Value Of Pitchers In Major League Baseball, Jonathan P. Wong
University of the Pacific Theses and Dissertations
The purpose of this thesis is to determine what effects draft order, monetary earnings, and Tommy John Surgery (TJS) have on the perceived value of a pitcher in Major League Baseball (MLB). For the context of this thesis, value will be defined as a player's ability to contribute to their team's wins in a positive manner. TJS has become synonymous with MLB and baseball as a sport, and many are either skeptical of its effects or over-assuming of its benefits. The three aforementioned areas of concerns were used to structure the thesis, as each dependent outcome is analyzed in a …
Thermodynamic Mechanisms Of Helix Stabilization In A Model Peptide And Protein, Ryan Murray
Thermodynamic Mechanisms Of Helix Stabilization In A Model Peptide And Protein, Ryan Murray
University of the Pacific Theses and Dissertations
Biologics are large, complex therapeutic agents generally produced from living organisms. One group of biologics is peptide/protein based. Biological agents offer unique advantages over traditional therapeutics including longer half-lives, higher specificity, greater efficacy, and reduced off-target effects. However, protein/peptide based drugs suffer from both delivery and stability issues. The higher order of protein structures (secondary, tertiary, etc.) derive ~80% of their conformational stability from paltry hydrophobic effects, with net stabilization of 5-15 kcal/mole observed for many proteins. Loss of conformational stability can lead to increased aggregation, precipitation, and degradation; and reduced activity and side effects. To increase stability and improve …
The Relationship Between The Educational Experiences Of Senior Dental Students And Their Attitudes Towards Intellectual And Developmental Disabilities, Alya Sarkhouah
University of the Pacific Theses and Dissertations
This research explores final year dental students’ knowledge and attitudes towards the treatment and management of patients with Intellectual and Developmental Disabilities (I/DD) as related to variations in the dental practices in Special Health Care Needs (SHCN) training they received. A quantitative, non-experimental study was conducted, employing survey data collection methods, to address descriptive, comparative, and correlational questions. One cohort, Class 2020, attended extramural rotations in specialized clinics for patients with I/DD and in-person lecture concerning this topic. However, due to the COVID-19 pandemic and its health-related restrictions, another cohort, Class 2021, did not have the same opportunity as rotations …
Optimizing The Human Aryl Hydrocarbon Receptor (Hahr) Expression In Pichia Pastoris, Junyu Qian
Optimizing The Human Aryl Hydrocarbon Receptor (Hahr) Expression In Pichia Pastoris, Junyu Qian
University of the Pacific Theses and Dissertations
The aryl hydrocarbon receptor (AHR) is a transcription factor which heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) to regulate downstream gene transcription. For the purpose of studying the crystal structure of human aryl hydrocarbon receptor (hAHR), it is essential to obtain abundant amount of pure recombinant protein.Basing on the benefits of using P. pastoris system to produce recombinant protein, including appropriate folding, secretion of interest proteins to the external environment of the cell, and easier purification process of protein due to the its limited production of endogenous secretory proteins [1], our lab chose P. pastoris yeast as the …
The Interrelationship Between Treatment, Ethnicity, And Structured Exercise In Clinical Populations, Amanda M. F. Lopez
The Interrelationship Between Treatment, Ethnicity, And Structured Exercise In Clinical Populations, Amanda M. F. Lopez
University of the Pacific Theses and Dissertations
Cancer is the second leading cause of death, with about approximately 1.9 million Americans being diagnosed each year. Yet, it has high survival rates with the help of advancing treatments like radiation therapy. Cancer patients and survivors are contingent on experiencing a decline in physical functioning, quality of life, and physiological parameters. Treatment is effective and can prolong life expectancy but can be deleterious to a patient’s health. Parallel with cancer's impact on Americans is cardiovascular disease. Cardiovascular disease is responsible for 1 in 4 deaths. The development of cardiovascular disease is not spread accordantly among all ethnicities. Hispanics are …
Optimization Of The Structure Of Ttr Ligands For Half-Life Extension (Tlhe), Guanming Jiang
Optimization Of The Structure Of Ttr Ligands For Half-Life Extension (Tlhe), Guanming Jiang
University of the Pacific Theses and Dissertations
Many potential therapeutic agents face challenges for their clinical development due to short circulation half-life. As a result, prolonging the half-life of therapeutic drugs in circulation while preserving their hydrophilicity and small size will be a key step toward more effective and safe pharmacological molecules. Our lab developed a new approach for enhancing the safety and efficacy of therapeutic agents. By endowing therapeutic agents with a hydrophilic small molecule (a derivative of the clinical candidate, AG10) which reversibly binds to the serum protein transthyretin (TTR), the half-life of the therapeutic agent should be extended by binding to the TTR in …
Investigation Of Cdk8 Inhibitor Q-12 Effects On Cdk8 And Cdk8 Substrates In Triple Negative Breast Cancer Cell Line Mda-Mb-468, Shengxi Li
University of the Pacific Theses and Dissertations
Cyclin-dependent kinases (CDKs) and cyclins (Cyclins) are the core molecules in the regulation mechanism of the entire cell cycle. Cell cycle dysregulation is a common feature of human cancers, and inhibitors of cyclin-dependent kinases (CDKs) play a crucial role in cell cycle control and are one of the most promising areas of cancer therapy. We aspired to use our cyclin-dependent kinase 8 (CDK8) inhibitor, Q-12, as a probe for biomarker discovery for CDK8 inhibitor sensitive tumor types. Q-12 shows potent inhibition of cell viability and induction of apoptosis process in some triple-negative breast cancer (TNBC) and colorectal cancer cell lines …
Peripherally Restricted Opioid Conjugates And Its Use As Pharmacological Probes And Potential Therapeutics, Md Tariqul Haque Tuhin
Peripherally Restricted Opioid Conjugates And Its Use As Pharmacological Probes And Potential Therapeutics, Md Tariqul Haque Tuhin
University of the Pacific Theses and Dissertations
Opioid-induced constipation (OIC) is one of the major adverse effects of opioid analgesics used by millions of patients each year. While progress has been made, there remains a significant unmet medical need in the treatment of OIC. Major gaps remain in our understanding of the role of the gastrointestinal tract and central nervous system (CNS) in precipitating OIC. For the last four decades, numerous investigations to study the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly believed to have limited penetration across the blood-brain barrier (BBB). Several preclinical and clinical …
Incorporating Glutamic Acid-Valine-Citrulline Linker In Trifunctional Molecules Targeting Psma Ensures Enhanced Stability, Safety, And Efficacy In Mouse Model Of Prostate Cancer, Toufiq Ul Amin
University of the Pacific Theses and Dissertations
This project describes the development of a new antitumor therapeutic platform that combines the benefits of small-molecule drug conjugates (SMDCs) and antibody drug conjugates (ADCs). Valine-citrulline (VCit) dipeptide linkers are popular cathepsin B cleavable ADC linkers. Due to its instability in mouse serum, translating efficacy data from mouse to human is more difficult. It has been reported that replacing the VCit linker with glutamic acid-valine-citrulline (EVCit) improves ADC stability in mouse serum. The effect of the EVCit linker on the stability of SMDCs has not been reported so far. In a xenograft mouse model of prostate cancer, we found that …
Spouses Of First Responders: A Narrative Inquiry Of Survival, Recovery And Healing, Jennifer D. Geiger
Spouses Of First Responders: A Narrative Inquiry Of Survival, Recovery And Healing, Jennifer D. Geiger
University of the Pacific Theses and Dissertations
The nature of the work of emergency responders (i.e., firefighters, law enforcement, paramedics, and dispatch) includes high stress and direct experiences of traumatic situations. The experience of posttraumatic stress is common. The spouse or significant other is often the first person to see a change in their responder and the person most likely to be sought out for support from the responder, yet there is little support for the spouses or significant others of emergency workers. The purpose of this qualitative study using in-depth interviews and narrative inquiry was to learn about participants’ experiences at the 6-day residential treatment (retreat) …