Medicine and Health Sciences Commons^™

A Guide To 'Under The Volcano', Gladys Marie Andersen

University of the Pacific Theses and Dissertations

Readers both before and after the publication of Malcolm Lowry's Under the Volcano frequently misunderstood Lowry's Method and consequently oversimplified His Beaning, Judging the novel to be over- written and carelessly constructed, they suggested cute or revisions. close reading, however, vindicates teary, who Insisted that extreme care had gone into his multi-leveled hovel and that any substantial deletions or modifications would bare the overall plan of his work.

Effects Of And Recovery From High And Low Oxygen Tensions On A Strain Of Mouse Fibroblasts Cultivated In Vitro, David Harold Shaw

University of the Pacific Theses and Dissertations

No abstract provided.

Sodium Borohydride Reduction Of Quinicine, David Arthur Dunnette

University of the Pacific Theses and Dissertations

Prom the dawn of history man has searched among the natural products of his environment for substances to com- bat his ills. The most widespread of these ills, malaria, today afflicts some 300 million people each year (1). The causative parasite, a protoza, in a somber of the Plasmodium genus and is transmitted through the saliva of the female Anopheles mosquito.

A Comparison Of The Fluidized Bed Drying Technique With Conventional Methods Of Drying Tablet Granulations, Kit Michael Mills

University of the Pacific Theses and Dissertations

Drying procedures, like other important unit operations in pharmacy, have received little attention in pharmaceutical literature. Within recent years, however, growing interest in these pharmaceutical engineering areas has become apparent.

Fluidization operations, although relatively unexplored in pharmacy, have been firmly established on a broad scale in other industries. Fluidization may be defined as the suspension and agitation of a bed of particulate solids by a vertically rising stream of gas. Each suspended particle is surrounded by the gas. This relative velocity of the gas and solid particles is high, although the gas velocity itself is relatively low. Heat is transferred …

The Preparation Of Coordination Compounds Of Rhodium (Iii) And Glutamic Acid And Substituted Glutamic Acids, Herman William Kalberer

University of the Pacific Theses and Dissertations

The father of coordination chemistry was Alfred Werner (1866- 1919). Werner's theory was largely responsible for the renewed interest in, and rapid growth of, inorganic chemistry around the turn of the century. He postulated that there were two types of valence, primary and secondary, which correspond, in modern terminology, to oxidation state and coordination number. The primary valences must be either negative ions, neutral molecules or, occasionally even, positive ions (11). He also postulated that the secondary valences are directed in space about the central ion, not only in the solid state, but also when the complex is in solution. …

An Investigation Of The Release Of 5-Fluorouracil From Ointment Bases, Vance Leroy Grainger

University of the Pacific Theses and Dissertations

During the several years in which this therapy has been developed and evaluated, as standard dermatological preparation has not been available. The objective of the present work was to study the release of 5-FU from various ointment bases and to attempt to determine the type of base which would release the compound most satisfactorily.

The methods chosen were designed to determine the release and penetration of 5-FU both by in vitro and in vivo methods. A modified agar plate method was chosen as the in vitro test for measuring release and subsequent diffusion into the agar. The penetration of the …

Studies On The Localization And Retention Of Tetracycline Hydrochloride In Ehrlich Ascites Cells, Dale William James

University of the Pacific Theses and Dissertations

The antibiotics have become so widely and successfully used in the practice of medicine that they are now considered to be essential. Among the antibiotics, the tetracycline group has achieved an enviable reputation for dependable medication, In spite of this, there remain several unanswered questions, One of these pertains to the interesting phenomenon for almost selective localization of tetracycline in certain tumor cells or masses, Although there have been numerous publications dealing with this phenomenon, as the following paragraphs will indicate, there is little agreement as to the factors involved. Indeed, there are some sharply conflicting opinions.

The investigations described …