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Full-Text Articles in Medicine and Health Sciences
Neurodevelopmental Expression Profile Of Dimeric And Monomeric Group 1 Mglurs: Relevance To Schizophrenia Pathogenesis And Treatment, Jeremy Lum, Francesca Fernandez-Enright, Natalie Matosin, Jessica L. Andrews, Xu-Feng Huang, Lezanne Ooi, Kelly A. Newell
Neurodevelopmental Expression Profile Of Dimeric And Monomeric Group 1 Mglurs: Relevance To Schizophrenia Pathogenesis And Treatment, Jeremy Lum, Francesca Fernandez-Enright, Natalie Matosin, Jessica L. Andrews, Xu-Feng Huang, Lezanne Ooi, Kelly A. Newell
Illawarra Health and Medical Research Institute
Group 1 metabotropic glutamate receptors (mGluR1/mGluR5) play an integral role in neurodevelopment and are implicated in psychiatric disorders, such as schizophrenia. mGluR1 and mGluR5 are expressed as homodimers, which is important for their functionality and pharmacology. We examined the protein expression of dimeric and monomeric mGluR1α and mGluR5 in the prefrontal cortex (PFC) and hippocampus throughout development (juvenile/adolescence/adulthood) and in the perinatal phencyclidine (PCP) model of schizophrenia. Under control conditions, mGluR1α dimer expression increased between juvenile and adolescence (209-328%), while monomeric levels remained consistent. Dimeric mGluR5 was steadily expressed across all time points; monomeric mGluR5 was present in juveniles, dramatically …
First-Stage Development And Validation Of A Web-Based Automated Dietary Modeling Tool: Using Constraint Optimization Techniques To Streamline Food Group And Macronutrient Focused Dietary Prescriptions For Clinical Trials, Yasmine Probst, Evan Morrison, Emma Sullivan, Hoa K. Dam
First-Stage Development And Validation Of A Web-Based Automated Dietary Modeling Tool: Using Constraint Optimization Techniques To Streamline Food Group And Macronutrient Focused Dietary Prescriptions For Clinical Trials, Yasmine Probst, Evan Morrison, Emma Sullivan, Hoa K. Dam
Faculty of Science, Medicine and Health - Papers: part A
No abstract provided.