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Full-Text Articles in Medicine and Health Sciences
A Lipidomic Analysis Of Placenta In Preeclampsia: Evidence For Lipid Storage, Simon H. J Brown, Samuel Eather, Dilys J. Freeman, Barbara J. Meyer, Todd W. Mitchell
A Lipidomic Analysis Of Placenta In Preeclampsia: Evidence For Lipid Storage, Simon H. J Brown, Samuel Eather, Dilys J. Freeman, Barbara J. Meyer, Todd W. Mitchell
Illawarra Health and Medical Research Institute
In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) …
Molecular Evidence Of Synaptic Pathology In The Ca1 Region In Schizophrenia, Natalie Matosin, Francesca Fernandez-Enright, Jeremy Lum, Martin Engel, Jessica L. Andrews, Nils C. Gassen, Klaus V. Wagner, Mathias V. Schmidt, Kelly A. Newell
Molecular Evidence Of Synaptic Pathology In The Ca1 Region In Schizophrenia, Natalie Matosin, Francesca Fernandez-Enright, Jeremy Lum, Martin Engel, Jessica L. Andrews, Nils C. Gassen, Klaus V. Wagner, Mathias V. Schmidt, Kelly A. Newell
Illawarra Health and Medical Research Institute
Alterations of postsynaptic density (PSD)95-complex proteins in schizophrenia ostensibly induce deficits in synaptic plasticity, the molecular process underlying cognitive functions. Although some PSD95-complex proteins have been previously examined in the hippocampus in schizophrenia, the status of other equally important molecules is unclear. This is especially true in the cornu ammonis (CA)1 hippocampal subfield, a region that is critically involved in the pathophysiology of the illness. We thus performed a quantitative immunoblot experiment to examine PSD95 and several of its associated proteins in the CA1 region, using post mortem brain samples derived from schizophrenia subjects with age-, sex-, and post mortem …