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Full-Text Articles in Medicine and Health Sciences

Beneficial Effects Of Increased Lysozyme Levels In Alzheimer's Disease Modelled In Drosophila Melanogaster, Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann-Christin Brorsson, Katarina Kagedal Jan 2016

Beneficial Effects Of Increased Lysozyme Levels In Alzheimer's Disease Modelled In Drosophila Melanogaster, Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann-Christin Brorsson, Katarina Kagedal

Illawarra Health and Medical Research Institute

Genetic polymorphisms of immune genes that associate with higher risk to develop Alzheimer's disease (AD) have led to an increased research interest on the involvement of the immune system in AD pathogenesis. A link between amyloid pathology and immune gene expression was suggested in a genome-wide gene expression study of transgenic amyloid mouse models. In this study, the gene expression of lysozyme, a major player in the innate immune system, was found to be increased in a comparable pattern as the amyloid pathology developed in transgenic mouse models of AD. A similar pattern was seen at protein levels of lysozyme …


Perspective: The Path To Confirming And Exploiting Potential Satiety-Enhancing Effects Of Sorghum-Based Foods For Human Diets, Anita Stefoska-Needham, Eleanor J. Beck, Linda C. Tapsell Jan 2016

Perspective: The Path To Confirming And Exploiting Potential Satiety-Enhancing Effects Of Sorghum-Based Foods For Human Diets, Anita Stefoska-Needham, Eleanor J. Beck, Linda C. Tapsell

Illawarra Health and Medical Research Institute

Consumer trends, particularly in populations burdened with high rates of obesity and overweight, indicate a growing demand for food products with specific satiety-enhancing effects to assist with appetite regulation and longer-term weight management. Sorghum whole grain, containing dietary fibre, slowly digestible starches and polyphenolic compounds, has been identified as a potential ingredient in the formulation of novel food products targeted for appetite control. Rigorous human clinical trials are necessary to build evidence for these purported effects, including studies that examine the underlying satiety-enhancing mechanisms. This paper provides perspectives on the path to confirming and exploiting potential satiety attributes of sorghum-based …


A 6-Month Randomised Controlled Trial Investigating Effects Of Mediterranean-Style Diet And Fish Oil Supplementation On Dietary Behaviour Change, Mental And Cardiometabolic Health And Health-Related Quality Of Life In Adults With Depression (Helfimed): Study Protocol, Dorota M. Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Kerin O'Dea, Sarah Blunden, Barbara J. Meyer, Leonie Segal, Natalie Parletta Jan 2016

A 6-Month Randomised Controlled Trial Investigating Effects Of Mediterranean-Style Diet And Fish Oil Supplementation On Dietary Behaviour Change, Mental And Cardiometabolic Health And Health-Related Quality Of Life In Adults With Depression (Helfimed): Study Protocol, Dorota M. Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Kerin O'Dea, Sarah Blunden, Barbara J. Meyer, Leonie Segal, Natalie Parletta

Faculty of Science, Medicine and Health - Papers: part A

Background: Modern diets, characterised by excess consumption of processed foods, are accompanied by an epidemic of chronic diseases. Cardiovascular disease and depression carry a large burden of disease and often occur together. Poor dietary patterns have been identified as an independent risk factor for depression while healthy diets with minimally processed food are protective. Traditional Mediterranean diets have been shown to reduce risk of cardiovascular disease; however there is a need for clinical trials in people with depression. This paper reports the study protocol of a Mediterranean-style diet intervention conducted in adults with self-reported depression. Methods/design: HELFIMED is a parallel …