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Full-Text Articles in Medicine and Health Sciences
Berberine Alleviates Olanzapine-Induced Adipogenesis Via The Ampkα-Srebp Pathway In 3t3-L1 Cells, Yan Jie Li, Xiaomin Zhao, Xiyu Feng, Xuemei Liu, Chao Deng, Chang-Hua Hu
Berberine Alleviates Olanzapine-Induced Adipogenesis Via The Ampkα-Srebp Pathway In 3t3-L1 Cells, Yan Jie Li, Xiaomin Zhao, Xiyu Feng, Xuemei Liu, Chao Deng, Chang-Hua Hu
Illawarra Health and Medical Research Institute
The aim of this study was to investigate the mechanisms underlying the inhibitory effects of berberine (BBR) on olanzapine (OLZ)-induced adipogenesis in a well-replicated 3T3-L1 cell model. Oil-Red-O (ORO) staining showed that BBR significantly decreased OLZ-induced adipogenesis. Co-treatment with OLZ and BBR decreased the accumulation of triglyceride (TG) and total cholesterol (TC) by 55.58% ± 3.65% and 49.84% ± 8.31%, respectively, in 3T3-L1 adipocytes accompanied by reduced expression of Sterol regulatory element binding proteins 1 (SREBP1), fatty acid synthase (FAS), peroxisome proliferator activated receptorγ (PPARγ), SREBP2, low-density lipoprotein receptor (LDLR), and hydroxymethylglutaryl-coenzyme A reductase (HMGR) genes compared with OLZ alone. …
First Proof Of Bismuth Oxide Nanoparticles As Efficient Radiosensitisers On Highly Radioresistant Cancer Cells, Callum Stewart, Konstantin K. Konstantinov, Sally Mckinnon, Susanna Guatelli, Michael L. F Lerch, Anatoly B. Rosenfeld, Moeava Tehei, Stephanie Corde
First Proof Of Bismuth Oxide Nanoparticles As Efficient Radiosensitisers On Highly Radioresistant Cancer Cells, Callum Stewart, Konstantin K. Konstantinov, Sally Mckinnon, Susanna Guatelli, Michael L. F Lerch, Anatoly B. Rosenfeld, Moeava Tehei, Stephanie Corde
Illawarra Health and Medical Research Institute
This study provides the first proof of the novel application of bismuth oxide as a radiosensitiser. It was shown that on the highly radioresistant 9L gliosarcoma cell line, bismuth oxide nanoparticles sensitise to both kilovoltage (kVp) or megavoltage (MV) X-rays radiation. 9L cells were exposed to a concentration of 50 μg.mL−1 of nanoparticle before irradiation at 125 kVp and 10 MV. Sensitisation enhancement ratios of 1.48 and 1.25 for 125 kVp and 10 MV were obtained in vitro, respectively. The radiation enhancement of the nanoparticles is postulated to be a combination of the high Z nature of the …