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Full-Text Articles in Medicine and Health Sciences
Intake Of 7,8-Dihydroxyflavone During Juvenile And Adolescent Stages Prevents Onset Of Psychosis In Adult Offspring After Maternal Immune Activation, Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Intake Of 7,8-Dihydroxyflavone During Juvenile And Adolescent Stages Prevents Onset Of Psychosis In Adult Offspring After Maternal Immune Activation, Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Illawarra Health and Medical Research Institute
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC). Furthermore, the adult offspring of poly(I:C)-treated mice showed cognitive deficits, prepulse inhibition (PPI) deficits, reduced BDNF-TrkB signaling, immunoreactivity of parvalbumin (PV) and peroxisome …
P2x7 Receptor Activation Causes Phosphatidylserine Exposure In Canine Erythrocytes, Megan Faulks, Tracey A. Kuit, Reece Sophocleous, Belinda L. Curtis, Stephen J. Curtis, Lisa M. Jurak, Ronald Sluyter
P2x7 Receptor Activation Causes Phosphatidylserine Exposure In Canine Erythrocytes, Megan Faulks, Tracey A. Kuit, Reece Sophocleous, Belinda L. Curtis, Stephen J. Curtis, Lisa M. Jurak, Ronald Sluyter
Faculty of Science, Medicine and Health - Papers: part A
AIM To determine if activation of the ATP-gated P2X7 receptor channel induces phosphatidylserine (PS) exposure in erythrocytes from multiple dog breeds. METHODS Peripheral blood was collected from 25 dogs representing 13 pedigrees and seven crossbreeds. ATP-induced PS exposure on canine erythrocytes in vitro was assessed using a flow cytometric Annexin V binding assay. RESULTS ATP induced PS exposure in erythrocytes from all dogs studied. ATP caused PS exposure in a concentrationdependent manner with an EC50 value of 395 μmol/L. The non-P2X7 agonists, ADP or AMP, did not cause PS exposure. The P2X7 antagonist, AZ10606120, but not the P2X1 antagonist, NF449, …