Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
The Management Of Tricyclic Antidepressant Poisoning: The Role Of Gut Decontamination, Extracorporeal Procedures And Fab Antibody Fragments, Paul I. Dargan, Mark G. Colbridge, Alison Jones
The Management Of Tricyclic Antidepressant Poisoning: The Role Of Gut Decontamination, Extracorporeal Procedures And Fab Antibody Fragments, Paul I. Dargan, Mark G. Colbridge, Alison Jones
Graduate School of Medicine - Papers (Archive)
Although there have been descriptive, uncontrolled clinical reports of removal of tablet debris by gastric lavage, there have been no clinical studies that have demonstrated that this has any impact on outcome in patients with tricyclic antidepressant (TCA) poisoning. There is also the possibility that lavage may increase drug absorption by pushing tablets into the small intestine. Furthermore, gastric lavage in patients with TCA poisoning may induce hypoxia and a tachycardia potentially increasing the risk of severe complications such as arrhythmias and convulsions. In view of the paucity of evidence that gastric lavage removes a significant amount of drug and …
Expression And Regulation Of Sterol 27-Hydroxylase (Cyp27a1) In Human Macrophages: A Role For Rxr And Pparγ Ligands, C M Quinn, W Jessup, Jenny Wong, L Kritharides, A Brown
Expression And Regulation Of Sterol 27-Hydroxylase (Cyp27a1) In Human Macrophages: A Role For Rxr And Pparγ Ligands, C M Quinn, W Jessup, Jenny Wong, L Kritharides, A Brown
Illawarra Health and Medical Research Institute
CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1 in a human macrophage-like cell-line, THP-1, and primary HMDMs (human monocyte-derived macrophages). In both macrophage cell types, we found that CYP27A1 expression is independent of cellular cholesterol levels and of LXR (liver X receptor)-dependent control of transcription. However, the RXR (retinoid X receptor) ligand, 9-cis-retinoic acid, upregulates CYP27A1 expression. Of the RXR heterodimeric partners tested, PPAR (peroxisome-proliferator-activated receptor) γ ligands significantly increased CYP27A1 mRNA levels. Its reversal by a PPARγ antagonist demonstrated the …