Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
The Molecular Mechanisms Underpinning The Therapeutic Properties Of Oleanolic Acid, Its Isomer And Derivatives For Type 2 Diabetes And Associated Complications, Danielle Camer, Yinghua Yu, Alexander Szabo, Xu-Feng Huang
The Molecular Mechanisms Underpinning The Therapeutic Properties Of Oleanolic Acid, Its Isomer And Derivatives For Type 2 Diabetes And Associated Complications, Danielle Camer, Yinghua Yu, Alexander Szabo, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Recent research has uncovered the molecular mechanisms responsible for the therapeutic properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular, recent reports have highlighted the benefits of these compounds in the prevention and treatment of type 2 diabetes and associated life-threatening complications, such as nonalcoholic fatty liver disease, nephropathy, retinopathy, and atherosclerosis. The prevalence of type 2 diabetes is of major concern since it is reaching global epidemic levels. Treatments targeting the signaling pathways altered in type 2 diabetes are being actively investigated, and OA and UA in natural and derivative forms are potential candidates …
Cytoprotective Properties Of Traditional Chinese Medicinal Herbal Extracts In Hydrogen Peroxide Challenged Human U373 Astroglia Cells, Megan L. Steele, John Truong, Suresh Govindaraghavan, Lezanne Ooi, Nikolaus J. Sucher, Gerald Munch
Cytoprotective Properties Of Traditional Chinese Medicinal Herbal Extracts In Hydrogen Peroxide Challenged Human U373 Astroglia Cells, Megan L. Steele, John Truong, Suresh Govindaraghavan, Lezanne Ooi, Nikolaus J. Sucher, Gerald Munch
Faculty of Science, Medicine and Health - Papers: part A
Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in normal ageing as well as in neurodegenerative processes. Since many of the constituents of herbal extracts are known antioxidants, it is believed that restoring oxidative balance may be one of the underlying mechanisms by which medicinal herbs can protect against ageing and cognitive decline. Based on the premise that astrocytes are key …