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Full-Text Articles in Medicine and Health Sciences
Open-Air Preservation Of Miniaturised Lithics: Experimental Research In The Cederberg Mountains, Southern Africa, Natasha Phillips, Justin Pargeter, Marika Low, Alex Mackay
Open-Air Preservation Of Miniaturised Lithics: Experimental Research In The Cederberg Mountains, Southern Africa, Natasha Phillips, Justin Pargeter, Marika Low, Alex Mackay
Faculty of Science, Medicine and Health - Papers: part A
Open-air archaeology plays a limited role in southern African Late Pleistocene research, with most studies focused on rock shelter assemblages. Recently, archaeologists have noted discrepancies in the composition of Late Pleistocene lithic assemblages between some of the region's open-air and rock shelter sites. For example, although relatively abundant in rock shelters, Late Pleistocene Later Stone Age (LSA, c. 44-12 kcal. BP) bipolar cores are rare in open-air contexts. In this paper, we assess this discrepancy by testing for differential preservation of specific artefact classes and sizes in semi-arid open-air conditions. We placed a replicated assemblage of miniaturised cores and flakes …
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background: In addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate how simvastatin impacts on experimental parkinsonian models via regulating NMDA receptors. Methodology/Principal Findings: Regional changes in NMDA receptors in the rat brain and anxiolytic-like activity were examined after unilateral medial forebrain bundle lesion by 6-hydroxydopamine via a 3-week administration of simvastatin. NMDA receptor alterations in the post-mortem rat brain were detected by [3H]MK-801(Dizocilpine) binding autoradiography. 6-hydroxydopamine treated PC12 was applied …
Effects Of Benzodiazepines, Antidepressants And Opioids On Driving: A Systematic Review And Meta-Analysis Of Epidemiological And Experimental Evidence, Tharaka L. Dassanayake, Patricia Michie, Gregory Carter, Alison L. Jones
Effects Of Benzodiazepines, Antidepressants And Opioids On Driving: A Systematic Review And Meta-Analysis Of Epidemiological And Experimental Evidence, Tharaka L. Dassanayake, Patricia Michie, Gregory Carter, Alison L. Jones
Graduate School of Medicine - Papers (Archive)
Background: Many individuals in the community are prescribed psychoactive drugs with sedative effects. These drugs may affect their daily functions, of which automobile driving is a major component. Objective: To examine the association of three classes of commonly used psychoactive drugs (viz. benzodiazepines and newer non-benzodiazepine hypnotics, antidepressants and opioids) with (i) the risk of traffic accidents (as indexed by epidemiological indicators of risk); and (ii) driving performance (as indexed by experimental measures of driving performance). Methods: A literature search for material published in the English language between January 1966 and January 2010 in PubMed and EMBASE databases was combined …
Human Lens Lipids Differ Markedly From Those Of Commonly Used Experimental Animals, Jane Deeley, Todd W. Mitchell, Xiaojia Wei, Jurgen Korth, Jessica Hughes, Stephen J. Blanksby, Roger J. Truscott
Human Lens Lipids Differ Markedly From Those Of Commonly Used Experimental Animals, Jane Deeley, Todd W. Mitchell, Xiaojia Wei, Jurgen Korth, Jessica Hughes, Stephen J. Blanksby, Roger J. Truscott
Faculty of Health and Behavioural Sciences - Papers (Archive)
Electrospray ionisation tandem mass spectrometry has allowed the unambiguous identification andquantification of individual lens phospholipids in human and six animal models. Using this approach ca. 100unique phospholipids have been characterised. Parallel analysis of the same lens extracts by a novel directinsertionelectron-ionization technique found the cholesterol content of human lenses to be significantlyhigher (ca. 6 times) than lenses from the other animals.The most abundant phospholipids in all the lenses examined were choline-containing phospholipids. In rat,mouse, sheep, cow, pig and chicken, thesewere present largely as phosphatidylcholines, in contrast 66% of thetotal phospholipid in Homo sapienswas sphingomyelin, with the most abundant being dihydrosphingomyelins,in …
Fish Recolonization In Temperate Australian Rockpools: A Quantitative Experimental Approach, Shane Griffiths, Ronald West, Andrew R. Davis, Ken Russell
Fish Recolonization In Temperate Australian Rockpools: A Quantitative Experimental Approach, Shane Griffiths, Ronald West, Andrew R. Davis, Ken Russell
Faculty of Science, Medicine and Health - Papers: part A
Understanding recolonization processes of intertidal fish assemblages is integral for predicting the consequences of significant natural or anthropogenic impacts on the intertidal zone. Recolonization of experimentally defaunated intertidal rockpools by fishes at Bass Point, New South Wales (NSW), Australia, was assessed quantitatively by using one long-term and two short-term studies. Rockpools of similar size and position at four sites within the intertidal zone were repeatedly defaunated of their fish fauna after one week, one month, and three months during two short-term studies in spring and autumn (5 months each), and every six months for the long-term study (12 months). Fish …
Jitter And Size Effects On Vection Are Immune To Experimental Instructions And Demands, Stephen A. Palmisano, Amy Y. Chan
Jitter And Size Effects On Vection Are Immune To Experimental Instructions And Demands, Stephen A. Palmisano, Amy Y. Chan
Faculty of Health and Behavioural Sciences - Papers (Archive)
Both coherent perspective jitter and explicit changing-size cues have been shown to improve the vection induced by radially expanding optic flow. The current study examined whether these stimulus-based vection advantages could be modified by altering cognitions/expectations about both the likelihood of self-motion perception and the purpose of the experiment. In the main experiment, participants were randomly assigned into two groups – one where the cognitive conditions biased participants towards self-motion perception and another where the cognitive conditions biased them towards object motion perception. Contrary to earlier findings by Lepecq et al (1995), we found that identical visual displays were less …