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Analysis Of The Psychological Impact Of A Vascular Risk Factor Intervention: Results From A Cluster Randomized Controlled Trial In Australian General Practice, Suzanne Helen Mckenzie, Upali W. Jayasinghe, Mahnaz Fanaian, Megan Passey, Mark Fort Harris
Analysis Of The Psychological Impact Of A Vascular Risk Factor Intervention: Results From A Cluster Randomized Controlled Trial In Australian General Practice, Suzanne Helen Mckenzie, Upali W. Jayasinghe, Mahnaz Fanaian, Megan Passey, Mark Fort Harris
Illawarra Health and Medical Research Institute
Background Screening for vascular disease, risk assessment and management are encouraged in general practice however there is limited evidence about the emotional impact on patients. The Health Improvement and Prevention Study evaluated the impact of a general practice-based vascular risk factor intervention on behavioural and physiological risk factors in 30 Australian practices. The primary aim of this analysis is to investigate the psychological impact of participating in the intervention arm of the trial. The secondary aim is to identify the mediating effects of changes in behavioural risk factors or BMI. Methods This study is an analysis of a secondary outcome …
Streptococcal Collagen-Like Protein A And General Stress Protein 24 Are Immunomodulating Virulence Factors Of Group A Streptococcus, James A. Tsatsaronis, Andrew Hollands, Jason N. Cole, Peter G. Maamary, Christine M. Gillen, Nouri L. Ben Zakour, Malak Kotb, Victor Nizet, Scott A. Beatson, Mark J. Walker, Martina L. Sanderson-Smith
Streptococcal Collagen-Like Protein A And General Stress Protein 24 Are Immunomodulating Virulence Factors Of Group A Streptococcus, James A. Tsatsaronis, Andrew Hollands, Jason N. Cole, Peter G. Maamary, Christine M. Gillen, Nouri L. Ben Zakour, Malak Kotb, Victor Nizet, Scott A. Beatson, Mark J. Walker, Martina L. Sanderson-Smith
Illawarra Health and Medical Research Institute
In Western countries, invasive infections caused by M1T1 serotype group A Streptococcus (GAS) are epidemiologically linked to mutations in the control of virulence regulatory 2-component operon (covRS). In indigenous communities and developing countries, severe GAS disease is associated with genetically diverse non-M1T1 GAS serotypes. Hypervirulent M1T1 covRS mutant strains arise through selection by human polymorphonuclear cells for increased expression of GAS virulence factors such as the DNase Sda1, which promotes neutrophil resistance. The GAS bacteremia isolate NS88.2 (emm 98.1) is a covS mutant that exhibits a hypervirulent phenotype and neutrophil resistance yet lacks the phage-encoded Sda1. Here, we have employed …