Medicine and Health Sciences Commons^™

Sound Assessment Of A Role For Fish Oil In Therapeutics Or Prevention Of Cardiovascular Disease Jeopardised By Confused Study Design, Peter L. Mclennan

Graduate School of Medicine - Papers (Archive)

The study by Galan and colleagues in the SU.FOL.OM3 collaborative group has added further confusion to the omega-3 story, which in this case largely derives from confusion in the study design. Confusion about the likely mechanism of cardiovascular protection and hence expected outcomes; confusion in the subject selection; confusion about the timing of intervention; confusion about the active components of fish oil.

Defining The Host Mucosal And Gut Microflora Interactions In Crohn's Disease Using Redundancy Analysis On Microarray Datasets, Caroline A. Kerr, J Shaw, Christopher S. Mcsweeney, Seungha Kang, M J. Buckley, T Lockett, Peter Pavlik

Graduate School of Medicine - Papers (Archive)

Introduction: Crohn’s disease (CD) is an inflammatory bowel disease that is characterised by chronic relapsing inflammation of the digestive tract. There is a significant body of evidence that suggests the intestinal mucosal microbiome interacts with the immune response to produce pathological inflammation and together these factors play a major role in the pathogenesis of CD. The aim of this study is to investigate interactions between the human intestinal mucosal transcriptome and mucosal microbiome using multivariate redundancy analysis on microarray datasets.

Methods: DNA and RNA were extracted from the same mucosal biopsies collected from CD patients (terminal ileum: n=5 from sites …

Embryonic Striatal Grafts Restore Bi-Directional Synaptic Plasticity In A Rodent Model Of Huntington's Disease, David M. Mazzocchi-Jones, Mate Dobrossy, Stephen Dunnett

Graduate School of Medicine - Papers (Archive)

Embryonic striatal grafts integrate with the host striatal circuitry, forming anatomically appropriate connections capable of influencing host behaviour. In addition, striatal grafts can influence host behaviour via a variety of non-specific, trophic and pharmacological mechanisms; however, direct evidence that recovery is dependent on circuit reconstruction is lacking. Recent studies suggest that striatal grafts alleviate simple motor deficits, and also that learning of complex motor skills and habits can also be restored. However, although the data suggest that such 're-learning' requires integration of the graft into the host striatal circuitry, little evidence exists to demonstrate that such integration includes functional synaptic …

Does Psychological Status Influence Clinical Outcomes In Patients With Inflammatory Bowel Disease (Ibd) And Other Chronic Gastroenterological Diseases: An Observational Cohort Prospective Study, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Gerald J. Holtmann, Jane M. Andrews

Graduate School of Medicine - Papers (Archive)

Background: Whether there is a temporal relationship between psychological problems and clinical outcomes in patients with diseases of the digestive tract has not been widely researched. Thus, our aims were 1) To observe and compare prospectively clinical outcomes in relation to psychological co-morbidity in patients with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and chronic hepatitis C (HCV) and, 2) To test the hypothesis that patients with psychological co-morbidities are less likely to have a satisfactory response to standard treatment at 12 months. Methods: Overall, 139 patients were enrolled in this observational cohort prospective study. Over the ensuing year, …

"It Doesn't Do Any Harm, But Patients Feel Better": A Qualitative Exploratory Study On Gastroenterologists' Perspectives On The Role Of Antidepressants In Inflammatory Bowel Disease, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann

Graduate School of Medicine - Papers (Archive)

Background: Interest in psychological factors in patients with inflammatory bowel disease (IBD) has increased in recent years. It has even been proposed that treating psychological co-morbidities with antidepressants may control disease activity and improve quality of life. Despite this, there is no data on gastroenterologists' attitudes to, and experiences with, antidepressant therapy in patients with IBD. Methods: We conducted semi-structured interviews with 18 gastroenterologists associated with metropolitan teaching hospitals. Qualitative content analysis was used to examine their responses. Results: Seventy-eight percent of gastroenterologists had treated IBD patients with antidepressants for pain, depression and/or anxiety, and insomnia. Antidepressants were reported to …

Antidepressants And Inflammatory Bowel Disease: A Systematic Review, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann

Graduate School of Medicine - Papers (Archive)

Background: A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological comorbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. Methods: We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. Results: 12 relevant publications were identified. All of them referred …