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A Mixed-Model Approach For The Analysis Of Cdna Microarray Gene Expression Data From Extreme-Performing Pigs After Infection With Actinobacillus Pleuropneumoniae, R J. Moser, A Reverter, Caroline A. Kerr, K J. Beh

Graduate School of Medicine - Papers (Archive)

We proposed a novel statistical approach for the analysis of cDNA experiments based on mixed-model methodology combined with mixtures of distributions. Our objective was to detect genes that may be involved in conferring heritable differences in susceptibility to common infections in intensive pig production. We employed a microarray expression profiling strategy and a mixed-model approach to the analysis of the expression data. A cDNA microarray of pig with 6,420 probes from immune tissues and cells was used to compare gene expression in peripheral blood leukocytes of two pigs showing extreme performance in their response to infection with Actinobacillus pleuropneumoniae. Principal …