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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri
Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri
Graduate College Dissertations and Theses
Glucose is widely recognized as the preferred energy substrate for metabolism by granulosa cells (GCs). Yet in most cells, 2-5% of glucose is shunted through the hexosamine biosynthesis pathway (HBP) for O-linked N-acetylglucosaminylation (O-GlcNAcylation). O-GlcNAcylation is an evolutionarily-conserved, post-translational process that modifies serine and threonine residues on a variety of proteins. O-GlcNAcylation is also considered a nutrient sensor that can regulate cellular processes such as metabolism, signal transduction, and proliferation. In this respect, O-GlcNAcylation may be similar to, and possibly mediate, AMP-activated protein kinase (AMPK) signaling and its nutrient-sensing actions. However, the occurrence of O-GlcNAcylation and its relative importance to …
Modeling The Heterogeneous Temporal Dynamics Of Epidemics On Networks, Andrea Joan Allen
Modeling The Heterogeneous Temporal Dynamics Of Epidemics On Networks, Andrea Joan Allen
Graduate College Dissertations and Theses
Mathematical models of infectious disease are important tools for understanding large-scale patterns of how a disease spreads through a population. Predictions of trends from disease models help guide public health prevention and mitigation measures. Most simple disease models assume that the population is randomly mixed, but real-world populations exhibit heterogeneous patterns in the way people interact. These differences in population structure can be represented by networks. Networks can then be incorporated into disease models by using various interdisciplinary concepts and tools. Yet even network disease models often overlook that populations change over time. In this thesis, two models of infectious …
Mitochondrial Dynamics Regulation Of The Lung Epithelial Response To Complex Allergen, Sierra White
Mitochondrial Dynamics Regulation Of The Lung Epithelial Response To Complex Allergen, Sierra White
Graduate College Dissertations and Theses
Asthma is a chronic inflammatory disease of the lungs that affects roughly 25 million Americans, costing the United States upwards of $80 billion annually in management and economic loss. The airway epithelium, which serves as the first line of defense against insults in the lung, are now appreciated as key contributors to initiation of this disease. A key regulator of the epithelial response to allergens and other inhaled irritants that can induce an allergic asthmatic response is the mitochondria. During an allergic response, the airway epithelial energy requirement changes, and mitochondrial function is altered, enhancing production of reactive oxygen species, …
Building A Learning Healthcare System: A Path To Optimizing Big Health Data To Inform Clinical Care Decisions, Danne Charlotte Emily Elbers
Building A Learning Healthcare System: A Path To Optimizing Big Health Data To Inform Clinical Care Decisions, Danne Charlotte Emily Elbers
Graduate College Dissertations and Theses
The explosive growth of data and computing power of the last decades has had large impacts on a myriad of domains, not in the least on one of society’s most complex systems: healthcare. In this work, a version of the resulting Learning Healthcare System (LHS) is explored and elements of it have been implemented and are in use at the Department of Veterans’ Affairs today. After an overview of what a LHS is and what it could be once executed in its full form, the chapters will describe in detail some of the individual elements and how they address cogs …
The Effect Of Amphibian Host Ecology And Evolution On The Pathogen Dynamics Of Ranavirus, Lauren V. Ash
The Effect Of Amphibian Host Ecology And Evolution On The Pathogen Dynamics Of Ranavirus, Lauren V. Ash
Graduate College Dissertations and Theses
Emerging infectious diseases threaten amphibian species around the globe. Ranavirus (Family: Iridoviridae) is associated with the majority of amphibian deaths in North America, with some species exhibiting mass mortality events in short periods of time. In contrast, some amphibian species show the capacity to resist or tolerate infection. Resistant individuals exhibit reduced infection intensity, while tolerant individuals display reduced fitness effects given the infection intensity. My research focused on how amphibian host dynamics at community, population, and individual-level scales relate to the wide variation in Ranavirus prevalence and severity. Through my work, I documented the first reports of Ranavirus in …
Determining The Effects Of Castration And Estrogen Replacement On Habit Development In Adult Male Long Evans Rats, Francesca Carasi-Schwartz
Determining The Effects Of Castration And Estrogen Replacement On Habit Development In Adult Male Long Evans Rats, Francesca Carasi-Schwartz
Graduate College Dissertations and Theses
During instrumental learning, behavior transitions from goal-directed actions to habits. Goal-directed behavior is driven by the value of the outcome while habitual responding develops with increased training and is characterized by the automaticity with which it occurs independent of outcome value. The dorsal striatum, one of the many regions of the brain that has been implicated in the conversion of goal-directed actions to habits, is sexually dimorphic, and ovarian hormones are known to modulate the expression of habit in females. The present experiments were performed to begin deciphering how gonadal steroid hormones influence habit development in male rats. In each …
Disruption Of Mitochondrial Trafficking In Lung Epithelial Cells Potentiates Allergic Asthma Phenotypes, Amelia M. Lamberty
Disruption Of Mitochondrial Trafficking In Lung Epithelial Cells Potentiates Allergic Asthma Phenotypes, Amelia M. Lamberty
Graduate College Dissertations and Theses
Allergic asthma is a serious socioeconomic and health issue that is characterized by chronic inflammation of the lungs and affects as many 300 million people worldwide of all ages. Inhaled environmental factors, such as allergens, can disrupt the airway epithelium, which is the physical barrier and the first line of defense against external irritants. Consequently, exposure to allergens can cause episodes of airway inflammation, increased mucus production and tissue remodeling, that leads to the obstruction and narrowing of the airways, which may present as difficulty breathing, wheezing, and persistent coughing. Unfortunately, there is no cure for allergic asthma, but allergen …
Experiences Participating In Federal Nutrition Assistance Programs During The Early Months Of The Covid-19 Pandemic: A Mixed Methods Study In Vermont, Emma Haven Spence
Experiences Participating In Federal Nutrition Assistance Programs During The Early Months Of The Covid-19 Pandemic: A Mixed Methods Study In Vermont, Emma Haven Spence
Graduate College Dissertations and Theses
For many Americans, the impacts of the COVID-19 pandemic have extended far beyond its overt health risks, spanning from economic shocks to new social realities. Elevated rates of both novel and continued food insecurity during the pandemic have been well-documented, and this burden has not been equally shared. Examination of food insecurity at the present moment offers a unique opportunity to give voice to those affected during this unprecedented time and understand the ability of existing social services to meet increased needs. This research aims to delve into the experiences of individuals at risk for food insecurity. Specifically, (1) to …