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Full-Text Articles in Medicine and Health Sciences
Lung Cancer And Kidney Injury: An Updated Review, Bhargav Patel, Mohammad Ebrahimi Kalan, Maryam Khosravian, Audrey C. Tolouian, Ramin Tolouian, Mahnaz Aboufazeli, Masoumeh Asgharpour, Amirhesam Alirezaei
Lung Cancer And Kidney Injury: An Updated Review, Bhargav Patel, Mohammad Ebrahimi Kalan, Maryam Khosravian, Audrey C. Tolouian, Ramin Tolouian, Mahnaz Aboufazeli, Masoumeh Asgharpour, Amirhesam Alirezaei
Nursing Faculty Publications
Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in …
The Role Of P62/Imp2 In Hepatocellular Carcinoma Progression, Mengtao Xing
The Role Of P62/Imp2 In Hepatocellular Carcinoma Progression, Mengtao Xing
Open Access Theses & Dissertations
The family of insulin- like growth factor 2 mRNA binding proteins (IMPs) contains three members: IMP1, p62/IMP2 and IMP3. All these proteins are oncofetal proteins, expressed during embryogenesis and lost in most tissues in adults. However, p62/IMP2 were found overexpressed in various cancers but its function in carcinogenesis remains to be investigated. Our previous studies found that p62/IMP2 was not only overexpressed in hepatocellular carcinoma (HCC) tissues, but also overexpressed in HCC cell lines. To explore the biological roles of p62/IMP2 in HCC progression, p62/IMP2 was knockout in two p62/IMP2 positive HCC cell lines (SNU449, HepG2). Due to the low …