Medicine and Health Sciences Commons^™

Combined Application Of Patient-Derived Cells And Biomaterials As 3d In Vitro Tumor Models, Asbiel Hasbum, Ozan Karabulut, Ruben Edgar Reyes, Claudio Ricci, Alessandro Franchi, Serena Danti, Sue Anne Chew

Health & Biomedical Sciences Faculty Publications and Presentations

Although advances have been made in cancer therapy, cancer remains the second leading cause of death in the U.S. and Europe, and thus efforts to continue to study and discover better treatment methods are ongoing. Three-dimensional (3D) tumor models have shown advantages over bi-dimensional (2D) cultures in evaluating the efficacy of chemotherapy. This commentary aims to highlight the potential of combined application of biomaterials with patient-derived cancer cells as a 3D in vitro model for the study and treatment of cancer patients. Five studies were discussed which demonstrate and provided early evidence to create 3D models with accurate microenvironments that …