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Full-Text Articles in Medicine and Health Sciences
A Cleft Lip And Palate Gene, Irf6, Is Involved In Osteoblast Differentiation Of Craniofacial Bone, Jake Thompson, Fabian Mendoza, Ethan Tan, Jessica Wildgrube Bertol, Arju S. Gaggar, Goo Jun, Cláudia Cristina Biguetti, Walid Fakhouri
A Cleft Lip And Palate Gene, Irf6, Is Involved In Osteoblast Differentiation Of Craniofacial Bone, Jake Thompson, Fabian Mendoza, Ethan Tan, Jessica Wildgrube Bertol, Arju S. Gaggar, Goo Jun, Cláudia Cristina Biguetti, Walid Fakhouri
School of Podiatric Medicine Publications and Presentations
Background:
Interferon Regulatory Factor 6 (IRF6) plays a critical role in embryonic tissue development including differentiation of epithelial cells. Besides orofacial clefting due to haploinsufficiency of IRF6, recent human genetic studies indicated that mutations in IRF6 are linked to small mandible and digit abnormalities. The function of IRF6 has been well studied in oral epithelium, however its role in craniofacial skeletal formation remains unknown. In this study, we investigated the role of Irf6 in craniofacial bone development using comparative analyses between wild-type and Irf6-null littermate mice
Results:
Immunostaining revealed the expression of IRF6 in hypertrophic chondrocytes, osteocytes …