Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Diabetes Screen During Tuberculosis Contact Investigations Highlights Opportunity For New Diabetes Diagnosis And Reveals Metabolic Differences Between Ethnic Groups, Blanca I. Restrepo, Léanie Kleynhans, Alejandra B. Salinas, Bassent Abdelbary, Happy Tshivhula, Genesis P. Aguillón-Durán, Carine Kunsevi-Kilola, Gloria Salinas, Kim Stanley, Juan C. Lopez-Alvarenga
Diabetes Screen During Tuberculosis Contact Investigations Highlights Opportunity For New Diabetes Diagnosis And Reveals Metabolic Differences Between Ethnic Groups, Blanca I. Restrepo, Léanie Kleynhans, Alejandra B. Salinas, Bassent Abdelbary, Happy Tshivhula, Genesis P. Aguillón-Durán, Carine Kunsevi-Kilola, Gloria Salinas, Kim Stanley, Juan C. Lopez-Alvarenga
School of Medicine Publications and Presentations
Type 2 diabetes (T2D) is a prevalent risk factor for tuberculosis (TB), but most studies on TB-T2D have focused on TB patients, been limited to one community, and shown a variable impact of T2D on TB risk or treatment outcomes. We conducted a cross-sectional assessment of sociodemographic and metabolic factors in adult TB contacts with T2D (versus no T2D), from the Texas-Mexico border to study Hispanics, and in Cape Town to study South African Coloured ethnicities. The prevalence of T2D was 30.2% in Texas-Mexico and 17.4% in South Africa, with new diagnosis in 34.4% and 43.9%, respectively. Contacts with T2D …
Analysis Of Ptprk Polymorphisms In Association With Risk And Age At Onset Of Alzheimer’S Disease, Cancer Risk, And Cholesterol, Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
Analysis Of Ptprk Polymorphisms In Association With Risk And Age At Onset Of Alzheimer’S Disease, Cancer Risk, And Cholesterol, Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
Health & Biomedical Sciences Faculty Publications and Presentations
The human receptor-type protein-tyrosine phosphatase kappa (PTPRK) gene is highly expressed in human brain and is previously associated with neuropsychiatric disorders and cancer. This study investigated the association of 52 single nucleotide polymorphisms (SNPs) in the PTPRK with the risk and age at onset (AAO) of Alzheimer’s disease (AD) in 791 AD patients and 782 controls. Five SNPs (top SNP rs4895829 with p=0.0125) were associated with the risk of AD based on a multiple logistic regression (p<0.05); while 6 SNPs (top SNP rs1891150 with p=8.02×10−6) were associated with AAO by using a multiple linear regression analysis. Interestingly, rs2326681 was associated with both the risk and AAO of AD (p=4.65×10−2 and 5.18×10−3, respectively). In a replication study, the results from family-based association test - generalized estimating equation (GEE) statistics and Wilcoxon test showed that seven SNPs were associated with the risk of AD (top SNP rs11756545 with p=1.02×10−2) and 12 SNPs were associated with the AAO (top SNP rs11966128 with p=1.39×10−4), respectively. One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p=4.1×10−3), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p=3.47×10−3), and 8 SNPs associated with total cholesterol (top SNP rs1012049 with p=6.09×10−3). In addition, the AD associated rs4895829 was associated with the gene expression level in the cerebellum (p=7.3×10−5). The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels.