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Anxiety Modulates The Relation Between Attention-Deficit/Hyperactivity Disorder Severity And Working Memory-Related Brain Activity, Dennis Van Der Meer, Pieter J. Hoekstra, Daan Van Rooij, Anderson M. Winkler, Hanneke Van Ewijk, Dirk J. Heslenfeld, Jaap Oosterlaan, Stephen V. Faraone, Barbara Franke, Jan K. Buitelaar
Anxiety Modulates The Relation Between Attention-Deficit/Hyperactivity Disorder Severity And Working Memory-Related Brain Activity, Dennis Van Der Meer, Pieter J. Hoekstra, Daan Van Rooij, Anderson M. Winkler, Hanneke Van Ewijk, Dirk J. Heslenfeld, Jaap Oosterlaan, Stephen V. Faraone, Barbara Franke, Jan K. Buitelaar
School of Medicine Publications and Presentations
OBJECTIVES: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have heightened levels of anxiety, which has been associated with worse performance on working memory tasks. Knowledge of the neural pathways underlying the combined presence of ADHD and anxiety may aid in a better understanding of their co-occurrence. Therefore, we investigated how anxiety modulates the effect of ADHD severity on neural activity during a visuospatial working memory (VSWM) task.
METHODS: Neuroimaging data were available for 371 adolescents and young adults participating in the multicentre cohort study NeuroIMAGE (average age 17.1 years). We analysed the effects of ADHD severity, anxiety severity and their …