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Exploring Novel Niclosamide Derivatives For Enhanced Efficacy In Human Glioblastoma U-87 Mg Cells: A Sar Investigation, Fernando Cisneros Iv, Benjamin Valdivia, Jihoo Woo, Shizue Mito Sep 2024

Exploring Novel Niclosamide Derivatives For Enhanced Efficacy In Human Glioblastoma U-87 Mg Cells: A Sar Investigation, Fernando Cisneros Iv, Benjamin Valdivia, Jihoo Woo, Shizue Mito

Research Colloquium

Glioblastoma, often referred to as glioblastoma multiforme (GBM), is the most aggressive and malignant type of primary brain tumor in adults. Glioblastoma is notoriously difficult to treat due to several inherent characteristics, such as its aggressiveness, heterogeneity, compartmentalization via the blood-brain barrier, resistance to most conventional therapies like chemotherapy and radiation, its location, and limited treatment options. Consequently, despite significant advancements in pharmacotherapies over the past 30 years, there has been only relatively minimal improvement in prognosis. Recent research into the effectiveness of niclosamide, an antihelminth drug, has yielded encouraging findings regarding its potential as a treatment for glioblastoma. Our …


Immunepotent Crp Enhances Cyclophosphamide-Induced Cytotoxicity Through A Caspase Independent But Ros Dependent Mechanism In Triple Negative-Breast Cancer Cells, Ana L. Rivera, A. C. Martínez-Torres, C. Rodríguez-Padilla Sep 2023

Immunepotent Crp Enhances Cyclophosphamide-Induced Cytotoxicity Through A Caspase Independent But Ros Dependent Mechanism In Triple Negative-Breast Cancer Cells, Ana L. Rivera, A. C. Martínez-Torres, C. Rodríguez-Padilla

Research Symposium

Background: Breast cancer (BC) is one of the leading causes of cancer death worldwide. Cyclophosphamide (CYP) remains a mainstay in cancer therapy mainly in the triple negative breast cancer subtype (TNBC) in spite of harmful adverse effects and cell death-resistances. To face this, combination of chemotherapies and immunotherapies has been proposed. IMMUNEPOTENT CRP (ICRP) is an immunotherapy that has cytotoxic effects in several cancer cells without affecting peripheral blood mononuclear cells (PBMC) and CD3+ cells, beside improving clinical parameters of chemotherapy-treated patients. The aim of this study was to evaluate the mechanism of cytotoxicity induced by ICRP in combination with …


Cyclophosphamide And Epirubicin Induce Apoptotic Cell Death In Microglia Cells, Rafael De La Hoz-Camacho Sep 2023

Cyclophosphamide And Epirubicin Induce Apoptotic Cell Death In Microglia Cells, Rafael De La Hoz-Camacho

Research Symposium

Background. Chemotherapy Related Cognitive Impairment’s (CRCI), diminish patient’s quality life, being breast cancer (BC) patients the most affected. Microglia is described to play a major role in CRCI; hence, the aim of this research was to describe the cytotoxicity of cyclophosphamide (CTX) and Epirubicin (EPI), on microglia (SIM-A9), compared to BC cells (4T1).

Methods. We assessed cell viability (Resazurin) and cell death (AnnV), as well as nuclear damage with γ-H2AX, p53, p16 and cell cycle analysis (PI staining) by flow cytometry (FC). Furthermore, we evaluated ΔΨm (DIOC6), ROS (DCFDA) and NO (DAF-FM) production. Finally, caspase activation (TF2-VAD-FMK) and autophagy (CYTO-ID). …