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Full-Text Articles in Medicine and Health Sciences
Enriched Environment Contributes To The Recovery From Neurotoxin-Induced Parkinson’S Disease Pathology, Daphne Alcala Zúñiga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Alejandro Lopez-Juarez, Masoud M. Zarei, Kelsey Baker, Mario Gil, Hansapani Rodrigo, Upal Roy
Enriched Environment Contributes To The Recovery From Neurotoxin-Induced Parkinson’S Disease Pathology, Daphne Alcala Zúñiga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Alejandro Lopez-Juarez, Masoud M. Zarei, Kelsey Baker, Mario Gil, Hansapani Rodrigo, Upal Roy
Health & Biomedical Sciences Faculty Publications and Presentations
Parkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with …
Gender-Specific Fine Motor Skill Learning Is Impaired By Myelin-Targeted Neurofibromatosis Type 1 Gene Mutation, Daniella P. Hernandez, Daniela M. Cruz, Celeste S. Martinez, Larisa M. Garcia, Ashley Figueroa, Marisol Villarreal, Liya M. Manoj, Saul Lopez, Karla D. López-Lorenzo, Alejandro Lopez-Juarez
Gender-Specific Fine Motor Skill Learning Is Impaired By Myelin-Targeted Neurofibromatosis Type 1 Gene Mutation, Daniella P. Hernandez, Daniela M. Cruz, Celeste S. Martinez, Larisa M. Garcia, Ashley Figueroa, Marisol Villarreal, Liya M. Manoj, Saul Lopez, Karla D. López-Lorenzo, Alejandro Lopez-Juarez
Health & Biomedical Sciences Faculty Publications and Presentations
Simple Summary
Most neurofibromatosis type 1 (NF1) patients present with neurological issues in parallel with abnormal brain white matter and myelin. Although links for NF1 neuropathophysiology and abnormal myelin were proposed long ago, no current data can openly support or refute this idea. Various studies suggest that Nf1 mutations affect myelin biology and function, but any impact on learning/memory remains unclear. Here, we show that mice with an Nf1 mutation induced in adult myelinating cells present learning, but not memory, issues in a voluntary fine motor skill test, the complex wheel (CW). The specific parameters shaping CW learning curves are …