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Full-Text Articles in Medicine and Health Sciences
The Roles Of Nuclear Receptor Nr4a1 In Cancer Cell Proliferation And Skeletal Muscle Differentiation, Alexa Farmer
The Roles Of Nuclear Receptor Nr4a1 In Cancer Cell Proliferation And Skeletal Muscle Differentiation, Alexa Farmer
Theses and Dissertations (ETD)
Nuclear receptors (NRs) constitute a major class of drug targets in the treatment of various cancer types. NRs respond to cellular signals and become activated upon ligand binding to transcriptionally modulate expression of target genes. NR4A1 (Nur77) is a member of the NR4A family of nuclear receptors and displays an oncogenic profile in many cancer models. It is often upregulated in adult solid malignancies and is known to promote cell proliferation and survival. Knockdown studies of NR4A1 in cancer cell lines results in decreased cell growth and angiogenesis and increased apoptosis, suggesting NR4A1 is an oncogenic protein. Due to the …
Novel Oncogenic Drivers In Pediatric Gliomagenesis, Alexander K. Diaz
Novel Oncogenic Drivers In Pediatric Gliomagenesis, Alexander K. Diaz
Theses and Dissertations (ETD)
Pediatric high-grade gliomas (pHGGs), with a two-year survival rate of less than 20%, are some of the most aggressive human cancers. This dissertation begins with our analysis of 127 pHGGs, including brainstem (BS) and non-brainstem (NBS) tumors, from 118 patients using next-generation sequencing technologies. Nearly one-third of BS-HGGs, also known as diffuse intrinsic pontine gliomas (DIPGs), harbored somatic heterozygous missense mutations in ACVR1, coding for a receptor serine-threonine kinase involved in bone morphogenetic protein (BMP) signaling. These alterations led to gain-of-function as evidenced by increased phosphorylation of downstream targets in primary astrocytes and zebrafish embryo ventralization. Whole-genome sequencing and …
Modulation Of The Magnetic Properties Of Aqueous Metal Ions And The Bioelectrodynamic Effects On Cancerous And Noncancerous Cells, Marcy C. Purnell
Modulation Of The Magnetic Properties Of Aqueous Metal Ions And The Bioelectrodynamic Effects On Cancerous And Noncancerous Cells, Marcy C. Purnell
Theses and Dissertations (ETD)
Bioelectrodynamics is the study of how electromagnetism affects the biophysical functions of living organisms by examining the effects on biochemical processing at the cellular level. The Cellular Energy Transfer Science (CETS) system modulates the magnetic behavior of aqueous metal ions by applying direct current (DC) with a Lorenz force to a hypotonic saline solution. This treated solution was then used to make growth media for cancerous and noncancerous cell lines in vitro. Exposure of cancerous and noncancerous cells to this media showed significant growth inhibition, cell cycle arrest, hyperpolarization of transmembrane potential and apoptosis of cancerous cells while not causing …