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Role Of Smad2 And Smad3 On Adipose Tissue Development And Function, Roshan Kumari
Role Of Smad2 And Smad3 On Adipose Tissue Development And Function, Roshan Kumari
Theses and Dissertations (ETD)
Introduction: Obesity and its associated metabolic syndrome are major medical problems worldwide including United States. Adipose tissue is the primary site of energy storage, playing important roles in health. Adipose tissue also has other critical functions, producing adipocytokines and contributing to normal nutrient metabolism, which in turn play important roles in satiety, inflammation, and total energy homeostasis. Activin A and activin B play important roles in maintaining body composition and energy homeostasis. This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.
SMAD2/3 proteins are downstream mediators of transforming growth factor-β (TGFβ) family signaling, including …