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Ampk Activation By Zyflamend: A Novel Pathway Regulating Metabolism And Growth In Prostate Cancer, Amber Frances Macdonald

Masters Theses

Zyflamend, a select blend of 10 herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer (CR-PCa), mediated in part by activating AMPK, a master energy sensor of the cell. Currently, two predominant upstream kinases are known to phosphorylate/activate AMPK at Thr172: LKB1, a known tumor suppressor, and CaMKK2, a tumor promotor over-expressed in a number of cancers. Thus, the overall objective was to interrogate how Zyflamend activates AMPK and determine the roles of LKB1 and CaMKK2 in this activation, by targeting upstream mediators of both kinases ± Zyflamend using pharmacologic and molecular techniques in CWR22Rv1 (CR-PCa …