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Differentiation Of Equine Mesenchymal Stromal Cells Into Cells Of Neural Lineage And Their Application Into A Novel Model For Acute Peripheral Nerve Injury In The Horse, Claudia Cruz
Masters Theses
Studies have shown that mesenchymal stromal cells (MSCs) are able to differentiate into extra-mesodermal lineages, including neurons. Positive outcomes were obtained after transplantation of neurally-induced MSCs in rats, rabbits and guinea pigs after nerve injury, but the effect of these cells is unknown in horses. Our objective was to test the ability of equine mesenchymal stromal cells to differentiate into cells of neuronal lineage, and to assess differences, if any, in morphology and protein expression. Additionally, we wanted to investigate if horse age and cell passage number contributed to the ability to achieve neural differentiation.
The first part of this …