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Biomarkers In The Detection Of Alzheimer’S Disease, Karen Kenny

Physician Assistant Scholarly Project Papers

Alzheimer’s Disease (AD) is a progressive form of dementia that affects memory, cognition, and functional ability. Although there are diagnostic tests being used to aid in the clinical diagnosis of AD, the only definitive method of diagnosis is through post-mortem biopsy of the brain. The purpose of this project and literature review is to investigate the most effective biomarkers when clinically evaluating AD. The main biomarkers of investigation include positron emission tomography (PET) imaging, cerebral spinal fluid (CSF), and blood-based biomarkers. The role of the apolipoprotein E (APOE4) gene as a genetic influence on AD was also evaluated within this …