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Full-Text Articles in Medicine and Health Sciences
Diagnostic Utility Of Cerebral White Matter Integrity In Early Alzheimer's Disease, David K. Johnson, Willis Barrow, Raeann E. Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns
Diagnostic Utility Of Cerebral White Matter Integrity In Early Alzheimer's Disease, David K. Johnson, Willis Barrow, Raeann E. Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns
Psychology Faculty Publications
We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study of aging and memory at the University of Kansas Medical Center. Structural magnetic resonance imaging and diffusion tensor imaging (DTI) including fractional anisotropy and mean diffusivity were performed on 27 patients with very mild dementia (Clinical Dementia Rating = 0.5) of the Alzheimer's type (DAT), and 32 cognitively normal subjects. Patient groups were compared across 6 volumetric measures and 14 DTI regions of interest. Very mildly demented patients showed …