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Full-Text Articles in Medicine and Health Sciences
Neuropsychiatric Profiles In Dementia, David K. Johnson, Amber S. Watts, Benjamin A. Chapin, Raeann E. Anderson, Jeffrey M. Burns
Neuropsychiatric Profiles In Dementia, David K. Johnson, Amber S. Watts, Benjamin A. Chapin, Raeann E. Anderson, Jeffrey M. Burns
Psychology Faculty Publications
We compared patterns of neuropsychiatric symptoms across 4 dementia types [Alzheimer disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB), and Parkinson disease dementia], and 2 mixed groups (AD/VAD and AD/DLB) in sample of 2,963 individuals from the National Alzheimer's Coordinating Center Uniform Data Set between September 2005 and June 2008. We used confirmatory factor analysis to compare neuropsychiatric symptom severity ratings made by collateral sources on the Neuropsychiatric Inventory Questionnaire for people with Clinical Dementia Rating scores of 1 or higher. A 3-factor model of psychiatric symptoms (mood, psychotic, and frontal) was shared across all dementia types. Between-group …
Diagnostic Utility Of Cerebral White Matter Integrity In Early Alzheimer's Disease, David K. Johnson, Willis Barrow, Raeann E. Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns
Diagnostic Utility Of Cerebral White Matter Integrity In Early Alzheimer's Disease, David K. Johnson, Willis Barrow, Raeann E. Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns
Psychology Faculty Publications
We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study of aging and memory at the University of Kansas Medical Center. Structural magnetic resonance imaging and diffusion tensor imaging (DTI) including fractional anisotropy and mean diffusivity were performed on 27 patients with very mild dementia (Clinical Dementia Rating = 0.5) of the Alzheimer's type (DAT), and 32 cognitively normal subjects. Patient groups were compared across 6 volumetric measures and 14 DTI regions of interest. Very mildly demented patients showed …