Medicine and Health Sciences Commons^™

Proton Pump Inhibitors (Ppis): A Review Of The Efficacy, Usage, And Current Literature Recommendations, Travis M. Booke

Physician Assistant Scholarly Project Posters

• As Klepser, Collier, and Cochran (2013) noted, PPIs are a class of agents that reduce acid secretion by parietal cells in the stomach by irreversibly blocking H+/K+ adenosine triphosphate. They are commonly prescribed for many gastrointestinal (GI) conditions including gastric and duodenal ulcers, gastroesophageal reflux disease (GERD), upper gastrointestinal bleeding, and Helicobacter pylori infections. They are frequently utilized in the primary care setting. The purpose of this study was to examine the efficacy, usage, and current literature on PPIs.

• There were several complications noted with PPI usage. Gomm et al. (2016) found that that use of PPI is …

A Review Of Barrett's Esophagus, Suzanne M. Zayan

Physician Assistant Scholarly Project Posters

Barrett’s Esophagus is a premalignant condition that predisposes patients to the development of esophageal adenocarcinoma.

•Esophageal adenocarcinoma dramatically rising over several decades; survival rates of less than 17% in a five year period.

•Management and treatment continues to evolve: use of radio-frequency ablation effective to treat low grade dysplasia

•Studies of risk factors and treatment options explored:

Efficacy and durability of endoscopic radiofrequency ablation for treatment of low grade dysplasia as option for metaplasia eradication

–Gastrointestinal pathologist expert reviews ensure identification of dysplasia prior to treatment
–Appropriate endoscopic surveillance intervals
–Gastroenterology guidelines for screening and surveillance for long term management …

Does Normalizing Gut Microbiota Decrease Exacerbation In Ibd, Franchesca Cook

Physician Assistant Scholarly Project Posters

Inflammatory bowel disease (IBD) including Crohn’s Disease (CD) and Ulcerative Colitis (UC) has become a more common diagnosis. The number of screenings for IBD has increased, drawing more attention to finding the cause. Researchers are finding that a change in diet, increased stress levels, and overuse of antibiotics may contribute to IBD by changing the gut microbiota (Skrautvol et al., 2011; Bernstein, 2010). Prebiotics and probiotics, an individualized anti-inflammatory diet, and lifestyle modification to decrease stress are all currently undergoing evaluation to discover a possible role in the reversal of IBD insult to the normal flora of the gut. This …

Comparing The Long Term Use Of H2 Antagonists (H2ras) And Proton Pump Inhibitors (Ppis) And The Incidence Of Colitis, Reiner Kremer

Physician Assistant Scholarly Project Posters

• Commonly used medications for GERD may affect the colonic mucosa

• H2 antagonists (H2RAs) ranitidine, cimetidine famotidine reduce acid secretion by 60 to 70%.

• Proton pump inhibitors (PPIs) omeprazole, pantoprazole, lansoprazole, esomeprazole and rabeprazole reduce acid secretion by inhibiting the H+ (proton) secreting pump, reducing hydrochloric acid by 80 to 95%.

• Diarrhea is one of the most commonly reported adverse events.

• H2RAs and PPIs have the physiological and functional potential to interfere with gastrointestinal physiology by altering intestinal pH.

• Microcytic colitis causing chronic diarrhea and colonic inflammation is a significant complication risk after the > 4-8 …

Comparing Fecal Microbiota Transplant (Fmt) To Vancomycin: In Treatment Of Recurrent Clostridium Difficile Infections (Cdi), Christopher Seil

Physician Assistant Scholarly Project Posters

• Clostridium difficile infection (CDI) is the main cause of antibiotic-associated pseudomembranous colitis.

• CDI has tripled over the last ten years due to the increased use of broad spectrum antibiotics. CDI has become increasingly difficult to manage with traditional therapies such as metronidazole and vancomycin due to mutations in the pathogen, resulting in resistant organisms.

• The purpose of this review was to determine if fecal microbiota transplantation (FMT) is more effective in treating and curing CDIs than traditional vancomycin therapy.

• The hypothesis was that FMT will have better treatment outcomes than traditional vancomycin therapy.

• The findings …

Celiac Disease: Advances In Diagnostic Testing?, Alicia A. Hanson

Physician Assistant Scholarly Project Posters

• Celiac disease (CD) is a gluten-sensitivity enteropathy that occurs in genetically susceptible individuals upon ingestion of gluten and resolves when gluten is withdrawn from one’s diet.

• Serological markers play a major role in the diagnosis of celiac disease, however a small intestinal biopsy is currently the gold standard in symptomatic individuals.

• The purpose of this study was to determine if serological testing alone is sufficient to confirm the diagnosis of CD and therefore eliminate the need for a biopsy.

• The review of literature explored studies that compared small intestinal biopsy with different serological testing in males …