Medicine and Health Sciences Commons^™

Communicating Pain Unseen: Addressing Health Outcomes In Sexual Activity For Women With Endometriosis, Madison Wiese

UNLV Theses, Dissertations, Professional Papers, and Capstones

Roughly 160 million women live with endometriosis, a chronic disease involving the uterine lining shedding on the outside of the uterus causing immense physical and emotional pain (Becker et al., 2020). One common symptom of endometriosis is dyspareunia, or painful sex (Ballard et al., 2008). This study aims to uncover how gender expectations from society impact women with endometriosis specifically in sexual encounters. Informed by the traditional sexual script theory and sexual script theory, the study examines how traditional gender norms might influence women’s prioritization of their own health needs as well as the physical, emotional, and relational health outcomes …

Protein Expression Of Steroid Receptors In Macaca Mulatta Endometriotic Lesions, Héctor Torres, Lynette Ruiz, Phd, Olga Gonzalez, Dvm, Luisa Morales, Drph

Journal of Health Disparities Research and Practice

Endometriosis is pathologically defined as the presence of endometrial tissue in ectopic locations. Currently, there are no specific, non-invasive biomarkers and no cure for endometriosis. Non-human primates (NHP), including Macaca mulatta (rhesus macaques), have been highlighted as appropriate models to study endometriosis due to genetic, physiological, and anatomical similarities to humans. Research shows endometriosis might be associated with molecular deviations in human peritoneal endometriosis, such as increased levels of estrogen receptors and decreased levels of progesterone receptors.

The aim of this study is to determine protein expression of steroid receptors in five endometriotic lesions of rhesus macaques. We propose that …

Elucidating The Expression Profile Of Ezh2 Isoforms In Endometriosis: An Immunohistochemical Study, John Soto-Vargas, Idhaliz Flores, Phd, Mariano Colón-Caraballo, Andrés Velázquez-Garcia

Journal of Health Disparities Research and Practice

Endometriosis is an estrogen-dependent gynecological disease that affects 1 out of 10 women of reproductive age causing severe pelvic pain and infertility. Factors including genetics, environment, inflammation, and recently epigenetics have been shown to play roles in the pathophysiology of this disease. Histone methylation is an epigenetic modification that modulates gene expression by causing changes in the chromatin structure. Trimethylation of histone 3 at lysine residue 27 (H3K27me3) is a histone mark related to gene repression. EZH2 is the histone methyltransferase (HMT) responsible of catalyzing H3K27me3. It has been shown that the EZH2 is involved in carcinogenesis; however, the specific …