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Modeling Impaired Hippocampal Neurogenesis After Radiation Exposure, Kapukotuwa Walawwe Sidath Chathuranga Kapukotuwa

UNLV Theses, Dissertations, Professional Papers, and Capstones

The birth of neuronal cells from neuronal stem cells is known as neurogenesis, and the granular cell layer of the dentate gyrus of hippocampus is one of the two regions in the brain this process occurs. Cognitive damages following radiation therapy for brain cancers in both children and adults have been linked to impairment of neurogenesis in the hippocampus. Studies followed using mice and rats as model animals have shown impairment in neurogenesis process following exposure to radiation. Obtaining experimental data for radiation-induced changes in neurogenesis in humans is very difficult. Model was developed and applied to mouse data previously; …