Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Role Of Micrornas In Alcohol-Induced Multi-Organ Injury., Sathish Kumar Natarajan, Joseph M. Pachunka, Justin L. Mott
Role Of Micrornas In Alcohol-Induced Multi-Organ Injury., Sathish Kumar Natarajan, Joseph M. Pachunka, Justin L. Mott
Journal Articles: Biochemistry & Molecular Biology
Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, …
Assessment Of Cardiovascular Physiology Using Dobutamine Stress Cardiovascular Magnetic Resonance Reveals Impaired Contractile Reserve In Patients With Cirrhotic Cardiomyopathy., Francisco Sampaio, Pablo Lamata, Nuno Bettencourt, Sophie Charlotte Alt, Nuno Ferreira, Johannes Tammo Kowallick, Joana Pimenta, Shelby Kutty, José Fraga, Michael Steinmetz, Paulo Bettencourt, Vasco Gama, Andreas Schuster
Assessment Of Cardiovascular Physiology Using Dobutamine Stress Cardiovascular Magnetic Resonance Reveals Impaired Contractile Reserve In Patients With Cirrhotic Cardiomyopathy., Francisco Sampaio, Pablo Lamata, Nuno Bettencourt, Sophie Charlotte Alt, Nuno Ferreira, Johannes Tammo Kowallick, Joana Pimenta, Shelby Kutty, José Fraga, Michael Steinmetz, Paulo Bettencourt, Vasco Gama, Andreas Schuster
Journal Articles: Pediatrics
BACKGROUND: Liver cirrhosis has been shown to affect cardiac performance. However cardiac dysfunction may only be revealed under stress conditions. The value of non-invasive stress tests in diagnosing cirrhotic cardiomyopathy is unclear. We sought to investigate the response to pharmacological stimulation with dobutamine in patients with cirrhosis using cardiovascular magnetic resonance.
METHODS: Thirty-six patients and eight controls were scanned using a 1.5 T scanner (Siemens Symphony TIM; Siemens, Erlangen, Germany). Conventional volumetric and feature tracking analysis using dedicated software (CMR42; Circle Cardiovascular Imaging Inc, Calgary, Canada and Diogenes MRI; Tomtec; Germany, respectively) were performed at rest and during low to …