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Impact Of A High-Fat Meal On Assessment Of Clopidogrel-Induced Platelet Inhibition In Healthy Subjects., Paul P. Dobesh, Jamela F. Urban, Scott W. Shurmur, Julie H. Oestreich
Impact Of A High-Fat Meal On Assessment Of Clopidogrel-Induced Platelet Inhibition In Healthy Subjects., Paul P. Dobesh, Jamela F. Urban, Scott W. Shurmur, Julie H. Oestreich
Journal Articles: Pharmacy Practice
BACKGROUND: Ideal conditions for platelet reactivity testing are critical for optimal selection of a P2Y12 inhibitor. Data are inconsistent regarding the impact of high-fat meals on test assessment.
METHODS: Participants included 12 healthy subjects not taking antiplatelet drugs after a 12-hour fast. After baseline assessment, subjects were given a 600 mg dose of clopidogrel. Four hours later, maximum platelet inhibition was tested in the fasting state by light transmission aggregometry (LTA), VerifyNow P2Y12, vasodilator-stimulated phosphoprotein (VASP), and whole blood aggregometry (WBA). Subjects were then provided a high-fat meal, and platelet function was evaluated two hours later. Change in measured platelet …