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S4s8-Rpa Phosphorylation As An Indicator Of Cancer Progression In Oral Squamous Cell Carcinomas., Jeff Rector, Sasha Kapil, Kelly J. Treude, Phyllis Kumm, Jason G. Glanzer, Brendan M. Byrne, Shengqin Liu, Lynette M. Smith, Dominick J. Dimaio, Peter J. Giannini, Russell B. Smith, Greg G. Oakley

Journal Articles: College of Dentistry

Oral cancers are easily accessible compared to many other cancers. Nevertheless, oral cancer is often diagnosed late, resulting in a poor prognosis. Most oral cancers are squamous cell carcinomas that predominantly develop from cell hyperplasias and dysplasias. DNA damage is induced in these tissues directly or indirectly in response to oncogene-induced deregulation of cellular proliferation. Consequently, a DNA Damage response (DDR) and a cell cycle checkpoint is activated. As dysplasia transitions to cancer, proteins involved in DNA damage and checkpoint signaling are mutated or silenced decreasing cell death while increasing genomic instability and allowing continued tumor progression. Hyperphosphorylation of Replication …