Medicine and Health Sciences Commons^™

Divergent Functions Of The Myotubularin (Mtm) Homologs Atmtm1 And Atmtm2 In Arabidopsis Thaliana: Evolution Of The Plant Mtm Family, Yong Ding, Ivan Ndamukong, Yang Zhao, Yuannan Xia, Jean-Jack Riethoven, David R. Jones, Nullin Divecha, Zoya Avramova

School of Biological Sciences: Faculty Publications

Myotubularin and myotubularin-related proteins are evolutionarily conserved in eukaryotes. Defects in their function result in muscular dystrophy, neuronal diseases, and leukemia in humans. In contrast to the animal lineage, where genes encoding both active and inactive myotubularins (phosphoinositide 3-phosphatases) have appeared and proliferated in the basal metazoan group, myotubularin genes are not found in the unicellular relatives of green plants. However, they are present in land plants encoding proteins highly similar to the active metazoan enzymes. Despite their remarkable structural conservation, plant and animal myotubularins have significantly diverged in their functions. While loss of myotubularin function causes severe disease phenotypes …

Anthropological Data Regarding The Adaptiveness Of Hebephilia, Raymond B. Hames, Ray Blanchard

Department of Anthropology: Faculty Publications

Hebephilia is the sexual attraction to early pubertal children in Tanner Stages 2 and 3, generally ages 11 through 14.

The second author of this letter (R.B.), a member of the Paraphilias Subworkgroup of the Work Group on Sexual and Gender Identity Disorders for DSM-5, proposed a diagnostic entity for DSM-5 that resembles the ICD-10 model, but with a different name: Pedohebephilic Disorder. In the original proposal (Blanchard, 2010a), this disorder would have three subtypes: pedophilic, hebephilic, and pedohebephilic. In the current version of the proposal, which is still under consideration, the name has been changed to Pedophilic Disorder, in …