Medicine and Health Sciences Commons^™

Neuroanatomical Substrates Of The Disruptive Effect Of Olanzapine On Rat Maternal Behavior As Revealed By C-Fos Immunoreactivity, Changjiu Zhao, Ming Li

Department of Psychology: Faculty Publications

Olanzapine is one of the most widely prescribed atypical antipsychotic drugs in the treatment of schizophrenia. Besides its well-known side effect on weight gain, it may also impair human parental behavior. In this study, we took a preclinical approach to examine the behavioral effects of olanzapine on rat maternal behavior and investigated the associated neural basis using the c-Fos immunohistochemistry. On postpartum Days 6–8, Sprague-Dawley mother rats were given a single injection of sterile water or olanzapine (1.0, 3.0 or 5.0 mg/kg, sc). Maternal behavior was tested 2 h later, after which rats were sacrificed and brain tissues were collected. …

Spectrum Of Acute Clinical Characteristics Of Diagnosed Concussions In College Athletes Wearing Instrumented Helmets, Ann-Christine Duhaime,, Jonathan G. Beckwith, Arthur C. Maerlender, Thomas W. Mcallister, Joseph J. Crisco, Stefan M. Duma, P. Gunnar Brolinson, Steven Rowson, Laura A. Flashman, Jeffrey J. Chu, Richard M. Greenwald

Department of Psychology: Faculty Publications

Object. Concussive head injuries have received much attention in the medical and public arenas, as concerns have been raised about the potential shortand long-term consequences of injuries sustained in sports and other activities. While many student athletes have required evaluation after concussion, the exact definition of concussion has varied among disciplines and over time. The authors used data gathered as part of a multiinstitutional longitudinal study of the biomechanics of head impacts in helmeted collegiate athletes to characterize what signs, symptoms, and clinical histories were used to designate players as having sustained concussions.

Methods. Players on 3 college …

Drug–Drug Conditioning Between Citalopram And Haloperidol Or Olanzapine In A Conditioned Avoidance Response Model: Implications For Polypharmacy In Schizophrenia, Nathan L. Sparkman, Ming Li

Department of Psychology: Faculty Publications

Patients with schizophrenia often have anxiety and depression, and thus are treated with multiple psychotherapeutic medications. This practice of polypharmacy increases the possibility for drug–drug interactions. However, the pharmacological and behavioral mechanisms underlying drug–drug interactions in schizophrenia remain poorly understood. In the present study, we adopted a preclinical approach and examined a less known behavioral mechanism, drug–drug conditioning (DDC) between haloperidol (a typical antipsychotic) or olanzapine (atypical antipsychotic) and citalopram (a selective serotonin reuptake inhibitor). A rat two-way conditioned avoidance response paradigm was used to measure antipsychotic activity and determine how DDC may alter the antipsychotic efficacy in this model. …

Parametric Studies Of Antipsychotic-Induced Sensitization In The Conditioned Avoidance Response Model: Roles Of Number Of Drug Exposure, Drug Dose, And Test–Retest Interval, Natashia Swalve, Ming Li

Department of Psychology: Faculty Publications

Repeated haloperidol and olanzapine treatment produces an enhanced disruption of avoidance responding, a validated measure of antipsychotic activity. Experimental parameters affecting this sensitization-like effect have not been thoroughly examined. The present study investigated the role of three parameters (number of injections, dose, and interval between initial exposure and challenge) in antipsychotic sensitization in the conditioned avoidance response paradigm. Well-trained Sprague–Dawley rats received different numbers of drug treatment (1–5 days) or different doses of haloperidol (0.025–0.10 mg/kg, subcutaneously) or olanzapine (0.5–2.0 mg/kg, subcutaneously). After certain time intervals (4, 10 or 17 days), they were tested for the expression of haloperidol or …

Neural Basis Of The Potentiated Inhibition Of Repeated Haloperidol And Clozapine Treatment On The Phencyclidine-Induced Hyperlocomotion, Changjiu Zhao, Tao Sun, Ming Li

Department of Psychology: Faculty Publications

Clinical observations suggest that antipsychotic effect starts early and increases progressively over time. This time course of antipsychotic effect can be captured in a rat phencyclidine (PCP)-induced hyperlocomotion model, as repeated antipsychotic treatment progressively increases its inhibition of the repeated PCP-induced hyperlocomotion. Although the neural basis of acute antipsychotic action has been studied extensively, the system that mediates the potentiated effect of repeated antipsychotic treatment has not been elucidated. In the present study, we investigated the neuroanatomical basis of the potentiated action of haloperidol (HAL) and clozapine (CLZ) treatment in the repeated PCP-induced hyperlocomotion. Once daily for five consecutive days, …

Staff Perceptions Of Risk For Prison Rape Perpetration And Victimization, Valerie M. Gonsalves, Kate Walsh, Mario J. Scalora

Department of Psychology: Faculty Publications

Copyright © 2012 SAGE Publications, http://tpj.sagepub.com Used by permission.

Communication-Based Assessment Of Developmental Age For Young Children With Developmental Disabilities, Shari L. Deveney, Lesa Hoffman, Cynthia J. Cress

Department of Psychology: Faculty Publications

Purpose: In this study, the authors compared a multiple-domain strategy for assessing developmental age of young children with developmental disabilities who were at risk for long-term reliance on augmentative and alternative communication (AAC) with a communication-based strategy composed of receptive language and communication indices that may be less affected by physically challenging tasks than traditional developmental age scores.

Method: Participants were 42 children (age 9–27 months) with developmental disabilities and who were at risk for long-term reliance on AAC. Children were assessed longitudinally in their homes at 3 occasions over 18 months using multiple-domain and communication-based measures. Confirmatory factor analysis …

Linking Outcomes From Peabody Picture Vocabulary Test Forms Using Item Response Models, Lesa Hoffman, Jonathan Templin, Mabel L. Rice

Department of Psychology: Faculty Publications

Purpose: The present work describes how vocabulary ability as assessed by 3 different forms of the Peabody Picture Vocabulary Test (PPVT; Dunn & Dunn, 1997) can be placed on a common latent metric through item response theory (IRT) modeling, by which valid comparisons of ability between samples or over time can then be made.

Method: Responses from 2,625 cases in a longitudinal study of 697 persons for 459 unique PPVT items (175 items from Peabody Picture Vocabulary Test—Revised [PPVT–R] Form M [Dunn & Dunn, 1981], 201 items from Peabody Picture Vocabulary Test—3 [PPVT–3] Form A [Dunn & Dunn, 1997], and …

Methamphetamine-Associated Psychosis, Kathleen M. Grant, Tricia D. Le Van, Sandra M. Wells, Ming Li, Scott F. Stoltenberg, Howard E. Gendelman, Gustavo Carlo, Rick A. Bevins

Department of Psychology: Faculty Publications

Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and …

Gender, Gender Roles, And Anxiety: Perceived Confirmability Of Self Report, Behavioral Avoidance, And Physiological Reactivity, Milena Stoyanova, Debra Anne Hope

Department of Psychology: Faculty Publications

Despite the well-documented gender effect in anxiety, less is known about contributing factors to women’s greater risk for anxiety and fears. The present study examined the relationship between gender, gender role orientation (i.e., expressivity/instrumentality) and fear of harmless insects (tarantula), using a multimodal approach of self-report measures, a Behavioral Approach Test (BAT), and physiological reactivity. Participants (144 college students; 67 women, 77 men) completed a questionnaire packet and then were instructed to approach a tarantula. We were unable to replicate Pierce and Kirkpatrick’s (1992) findings that men underreport anxiety. Consistent with the literature, women in the study experienced greater anxiety …

Differential Effects Of Acute Amphetamine And Phencyclidine Treatment And Withdrawal From Repeated Amphetamine Or Phencyclidine Treatment On Social Interaction And Social Memory In Rats, Ming Li, Wei He, Rebecca Munro

Department of Psychology: Faculty Publications

Although animal models based on amphetamine (AMPH) or phencyclidine (PCP) treatment have been used extensively to study the neurobiological and behavioral characteristics of schizophrenia, there are conflicting reports regarding their validity in modeling the negative symptoms and cognitive deficits of schizophrenia. The present study examined how acute AMPH or PCP treatment (Experiment 1) and withdrawal from repeated AMPH treatment (Experiment 2) or PCP treatment (Experiment 3) affects social behavior and social recognition memory in male Sprague-Dawley rats. Each subject was tested on two consecutive days. On the first day, the rats were tested four times (5 min/each) at 10-min intervals …

Integrating Sexual Objectification With Object Versus Person Recognition: The Sexualized-Body-Inversion Hypothesis, Philippe Bernard, Sarah J. Gervais, Jill Allen, Sophie Campomizzi, Olivier Klein

Department of Psychology: Faculty Publications

In the study reported here, we tested the novel sexualized-body-inversion hypothesis. Integrating research and theory on objectification and person versus object recognition, we examined whether sexualized women, but not sexualized men, are recognized in the same way as objects are. According to objectification theory (Fredrickson & Roberts, 1997), female bodies are scrutinized and evaluated to a greater degree than male bodies are, which leads to sexual objectification of women. Defined as viewing or treating an individual as a sexualized body, or as sexualized body parts, available for satisfying the needs and desires of other people (Bartky, 1990), sexual objectification has …

Contextual And Behavioral Control Of Antipsychotic Sensitization Induced By Haloperidol And Olanzapine, Chen Zhang, Ming Li

Department of Psychology: Faculty Publications

Repeated administration of haloperidol (HAL) and olanzapine (OLZ) causes a progressively enhanced disruption of the conditioned avoidance response (CAR) and a progressively enhanced inhibition of phencyclidine (PCP)-induced hyperlocomotion in rats (termed antipsychotic sensitization). Both actions are thought to reflect intrinsic antipsychotic activity. The present study examined the extent to which antipsychotic- induced sensitization in one model (e.g. CAR) can be transferred or maintained in another (e.g. PCP hyperlocomotion) as a means of investigating the contextual and behavioral controls of antipsychotic sensitization. Well-trained male Sprague-Dawley rats were first repeatedly tested in the CAR or the PCP (3.2 mg/kg, subcutaneously) hyperlocomotion model …

Intertemporal Choice In Lemurs, Jeffrey R. Stevens, Nelly Mühlhoff

Department of Psychology: Faculty Publications

Different species vary in their ability to wait for delayed rewards in intertemporal choice tasks. Models of rate maximization account for part of this variation, but other factors such as social structure and feeding ecology seem to underly some species differences. Though studies have evaluated intertemporal choice in several primate species, including Old World monkeys, New World monkeys, and apes, prosimians have not been tested. This study investigated intertemporal choices in three species of lemur (black-and- white ruffed lemurs, Varecia variegata, red ruffed lemurs, Varecia rubra, and black lemurs, Eulemur macaco) to assess how they compare to …

Clozapine, But Not Olanzapine, Disrupts Conditioned Avoidance Response In Rats By Antagonizing 5-Ht2a/2c Receptors, Ming Li, Tao Sun, Alexa Mead

Department of Psychology: Faculty Publications

The present study was designed to assess the role of 5-HT_2A/2C receptors in the acute and repeated effect of clozapine and olanzapine in a rat conditioned avoidance response model, a validated model of antipsychotic activity. Male Sprague–Dawley rats that were previously treated with either phencyclidine (0.5–2.0 mg/kg, sc), amphetamine (1.25–5.0 mg/kg, sc), or saline and tested in a prepulse inhibition of acoustic startle study were used. They were first trained to acquire avoidance response to a white noise (CS1) and a pure tone (CS2) that differed in their ability to predict the occurrence of footshock. Those who acquired avoidance …

Confirmatory Factor Analysis Of The Preschool Behavioral And Emotional Rating Scale (Prebers) With Preschool Children With Disabilities, Cynthia J. Cress, Lori Synhorst, Michael Epstein, Elizabeth Allen

Department of Psychology: Faculty Publications

The Preschool Behavioral and Emotional Rating Scale (PreBERS) is a standardized, norm-referenced instrument that assesses emotional and behavioral strengths of preschool children. This study investigated whether the PreBERS four-factor structure (i.e., emotional regulation, school readiness, social confidence, and family involvement) could be replicated with an early childhood special education (ECSE) sample of children. Teachers who participated in the study rated a total of 1,103 preschool children with disabilities. Confirmatory factor analysis determined the extent to which the ECSE data fit the original four-factor PreBERS structure identified with the national normative sample. Results indicated that the four-factor structure demonstrated an acceptable …

Conditioned Response Evoked By Nicotine Conditioned Stimulus Preferentially Induces C-Fos Expression In Medial Regions Of Caudate-Putamen, Sergios Charntikov, Matthew E. Tracy, Changjiu Zhao, Ming Li, Rick A. Bevins

Department of Psychology: Faculty Publications

Nicotine has both unconditioned and conditioned stimulus properties. Conditioned stimulus properties of nicotine may contribute to the tenacity of nicotine addiction. The purpose of this experiment was to use neurohistochemical analysis of rapidly developing c-Fos protein to elucidate neurobiological loci involved in the processing of nicotine as an interoceptive conditioned stimulus (CS). Rats were injected (SC) in an intermixed fashion with saline or nicotine (16 sessions of each) and placed in conditioning chambers where they were given one of the three conditions depending on group assignment: (a) nicotine paired 100% of the time with intermittent access to sucrose (nicotine-CS condition), …