Open Access. Powered by Scholars. Published by Universities.®
University of Nebraska - Lincoln
Department of Biochemistry: Dissertations, Theses, and Student Research
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Er-Associated Degradation And Cadmium Dependent Rescue Of Pca1, Nathan Smith
Er-Associated Degradation And Cadmium Dependent Rescue Of Pca1, Nathan Smith
Department of Biochemistry: Dissertations, Theses, and Student Research
Protein synthesis and proper folding is an essential process for all organisms. In eukaryotes proteins of the secretory pathway are synthesized and inserted into the lumen or membrane of the endoplasmic reticulum. Eukaryotic cells maintain a mechanism for removal of proteins unable to fold properly. This process is known as ER-associated degradation (ERAD). A poorly functioning ERAD can lead to a build-up of misfolded proteins which has been implicated in several degenerative diseases such as Alzheimer’s, Amyotrophic lateral sclerosis, and Parkinson’s. Thus, the study of how proteins are recognized, extracted from the ER, and degraded is essential for determining methods …