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Synergistic Inhibition Of Bovine Leukemia Virus Replication In Vitro By Ribavirin And Alpha-Interferon [Abstract Only], Jeffrey Isaacson, Charles Wood, Jay Reddy

Jay Reddy Publications

Bovine leukemia virus (BLV) is an oncogenic retrovirus that infects cattle. It is classified in the human T-cell leukemia virus (HTLV) group, although BLV mainly infects B cells rather than T cells. Most BLV-infected cattle remain asymptomatic, but about 30% develop persistent lymphocytosis, and perhaps 5% eventually acquire B-cell lymphoma. Mainly as a result of the latter condition, BLV is a significant economic problem for cattle producers worldwide. Moreover, because of the close genetic similarities between the two viruses, BLV may also be a useful model for investigating HTLV-associated diseases in humans. The prognosis of HTLV-I-associated disease is generally poor …