Medicine and Health Sciences Commons^™

Helmet Laws And Motorcycle Rider Death Rates, Charles C. Branas, M. Margaret Knudson

Public Health Resources

We investigated motorcycle rider death rates between states with full motorcycle helmet laws and those without. This was done using both unadjusted bivariate analyses and multivariate random-effects generalized least squares regression models of rider death rates. Multivariate models were adjusted for the competing influences of several explanatory variables, including the existence of a motorcycle helmet law. From 1994 to 1996, states with helmet laws experienced a median death rate of 6.20 riders per 10 000 registered motorcycles and states without helmet laws experienced a median death rate of 5.07 riders per 10 000 registered motorcycles (P=0.008). After controlling for other …

Evidence For Nonacetylcholinesterase Targets Of Organophosphorus Nerve Agent: Supersensitivity Of Acetylcholinesterase Knockout Mouse To Vx Lethality, Ellen G. Duysen, Bin Li, Weihua Xie, Lawrence M. Schopfer, Robert S. Anderson, Clarence A. Broomfield, Oksana Lockridge

Public Health Resources

The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice. Mice (34–55 days old) were grouped for this study, after it was determined that AChE, butyrylcholinesterase (BChE), and carboxylesterase activities had reached stable values by this age. Mice with 0, 50, or 100% AChE activity were treated subcutaneously with the nerve agent VX. The LD₅₀ for VX was 10 to 12 µg/kg in AChE-/-, 17 µg/kg in AChE+/-, and 24 µg/kg in AChE+/- mice. The same cholinergic signs of toxicity were present in AChE-/- mice as …

Characterization Of Immunoglobulin Binding To Isolated Human Erythrocyte Membranes: Evidence For Selective, Temperature-Induced Binding Of Naturally Occurring Autoantibodies To The Cytoskeleton, James M. Salhany, Karen S. Cordes, Renee L. Sloan

Public Health Resources

Human plasma contains naturally occurring autoantibodies to the predominant components of the erythrocyte membrane: band 3 and spectrin bands 1 and 2 of the cytoskeleton. The titer of cytoskeletal plasma autoantibodies increases in various hemolytic conditions, suggesting that opsonization of the cytoskeleton may play an important role in the clearance of hemolyzed (not senescent) erythrocytes from the circulation. In this study, we use Alexa Fluor 488 goat anti-human IgG conjugate (Molecular Probes, Eugene, OR, USA), to characterize plasma immunoglobulin binding to erythrocyte membranes from osmotically hemolyzed cells (`ghosts'). The results show that exposure of ghosts to plasma results in 4-fold …

Borrelia Lonestari Infection After A Bite By An Amblyomma Americanum Tick, Angela M. James, Dionysios Liveris, Gary P. Wormser, Ira Schwartz, Marisa A. Montecalvo, Barbara J. B. Johnson

Public Health Resources

Erythematous rashes that are suggestive of early Lyme disease have been associated with the bite of Amblyomma americanum ticks, particularly in the southern United States. However, Borrelia burgdorferi, the causative agent of Lyme disease, has not been cultured from skin biopsy specimens from these patients, and diagnostic serum antibodies usually have not been found. Borrelia lonestari sp nov, an uncultured spirochete, has been detected in A. americanum ticks by DNA amplification techniques, but its role in human illness is unknown. We observed erythema migrans in a patient with an attached A. americanum tick. DNA amplification of the flagellin gene …

The Unequal Cancer Burden: Efforts Of The Centers For Disease Control And Prevention To Bridge The Gap Through Public Health, Nancy C. Lee

Public Health Resources

Despite the broad advances made in cancer research and interventions in the last quarter of a century, inequality still persists as we confront challenges arising from the unequal burden of cancer among Americans. Some racial and ethnic minorities, people with low incomes, those in rural areas, and other medically underserved populations suffer disproportionately from cancer. We know, for example, that African Americans are about 34% more likely to die of cancer than whites and more than two times more likely to die of cancer than Asian/Pacific Islanders, American Indians, or Hispanics.

Disparities also exist among the major racial and ethnic …