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Natural Killer Cell Transcript 4 Promotes The Development Of Sjӧgren's Syndrome Via Activation Of Rap1 On B Cells, Peng Qu, Todd Wuest, Yongfen Min, Ilias Alevizos, Howard A. Young, P. Charles Lin
Natural Killer Cell Transcript 4 Promotes The Development Of Sjӧgren's Syndrome Via Activation Of Rap1 On B Cells, Peng Qu, Todd Wuest, Yongfen Min, Ilias Alevizos, Howard A. Young, P. Charles Lin
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Autoimmune disorders are the third most common diseases in the United States, and affect the daily lives of millions of people. In this study, we analyzed patient samples, utilized a transgenic mouse model and human B cells to reveal Natural Killer Cell Transcript 4 (NK4) as a novel regulator that promotes the development of autoimmune disorders. NK4 was significantly elevated in samples from patients with Sjӧgren's Syndrome (SS). SS patients show elevated NK4 levels. There is a strong and positive correlation between the increased levels of NK4 and the duration of SS. Interestingly, transgenic expression of NK4 in a mouse …