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Full-Text Articles in Medicine and Health Sciences
The International Cannabis Toolkit (Icanntoolkit): A Multidisciplinary Expert Consensus On Minimum Standards For Measuring Cannabis Use, Valentina Lorenzetti, Chandni Hindocha, Kat Petrilli, Paul Griffiths
The International Cannabis Toolkit (Icanntoolkit): A Multidisciplinary Expert Consensus On Minimum Standards For Measuring Cannabis Use, Valentina Lorenzetti, Chandni Hindocha, Kat Petrilli, Paul Griffiths
Faculty and Student Publications
Background: The lack of an agreed international minimum approach to measuring cannabis use hinders the integration of multidisciplinary evidence on the psychosocial, neurocognitive, clinical and public health consequences of cannabis use. Methods: A group of 25 international expert cannabis researchers convened to discuss a multidisciplinary framework for minimum standards to measure cannabis use globally in diverse settings. Results: The expert-based consensus agreed upon a three-layered hierarchical framework. Each layer—universal measures, detailed self-report and biological measures—reflected different research priorities and minimum standards, costs and ease of implementation. Additional work is needed to develop valid and precise assessments. Conclusions: Consistent use of …
Efficacy Of Δ-9-Tetrahydrocannabinol For Hiv-Related Neuropathic Pain, Kaia Horne
Efficacy Of Δ-9-Tetrahydrocannabinol For Hiv-Related Neuropathic Pain, Kaia Horne
Honors Theses
Despite the availability and success of antiretroviral therapeutics, ~30% of patients living with HIV experience neuropathic pain that is often intractable. The mechanisms are not known, but there is evidence to support a role for the HIV virotoxins, Tat and/or gp120, which can damage or degenerate neurons and peripheral nerves. One mechanism by which Tat and gp120 promote nerve damage involves the stimulation of proinflammatory cytokine production from immune cells which can damage or kill bystander cells. Notably, compounds found in Cannabis exert anti-inflammatory effects and many studies report HIV patients to consume more marijuana than seronegative individuals. When people …