Medicine and Health Sciences Commons^™

Health Insurance And The Undocumented Immigrant, Anja Diercks

Honors Theses

The purpose of this thesis is to perform a comparative analysis on how seven different countries (USA, South Africa, Germany, England, Canada, France and Singapore) organize their healthcare system to cope with the issue of undocumented immigrants and whether or not these systems in place were “fair.” The thesis will also explore the possible ways the United States could change to be more inclusive and fairer in the world of healthcare and health insurance for the undocumented immigrant. A study on what fairness means both in ethical and economical terms is done to suggest a new basis of a fair …

Effects Of Prolonged Downhill Running On Upper Body Muscle Functions, Robert J. Benton

Honors Theses

Downhill running exercise has shown damaging effects on the lower body muscles. However, its effects on the remote nonlocal upper limb muscle’s neuromuscular functions are not well studied. Purpose: To examine the potential effects of a 1-hour downhill running exercise on the elbow flexor muscle neuromuscular functions and performance. Methods: Seventeen healthy and physically active young adults (Control: n = 9; Running: n = 8) participated in and completed this study. The Control group rested for 30 minutes while the Running group performed 1-hour of downhill running at a 10% decline on a treadmill. Before (Pre), immediately after (Post), 24 …

The Histone Deacetylase Inhibitor Largazole: A Potential Chemotherapeutic Agent, Hannah Lynn Carson

Honors Theses

Histone deacetylase enzymes are known for their inherent activity as epigenetic modifiers. Although, they have become recognized for their role in cancer progression and other diseases. But also, histone deacetylases have other non-histone targets, for example, microtubules, which play important roles in cancer metastasis, apoptosis, and replication. With histone deacetylase inhibitors (HDACi), our research explored HDACi effects on breast cancer cell lines. The overall goal was to understand the potential of largazole, a class one histone deacetylase inhibitor on breast cancer cell lines. The research consisted of two parts: sulforhodamine B (SRB) viability assays under hypoxic and normoxic conditions. The …

The Effects Of Alpha-Tocopherol And Ascorbic Acid On Metastatic Breast Cancer Cells, Scout Treadwell

Honors Theses

Breast cancer is a multifaceted, complex disease that affects hundreds of thousands of patients every year. Although there has a been a decline in the mortality rate of this disease, it is still vital to investigate and discover new possible treatments. One area of research involves the generation of reactive oxygen species (ROS) in cancer cells and the possibility of ROS-induced apoptosis. Antioxidants such as Vitamin C and Vitamin E have been shown to serve as pro-oxidants. Instead of detoxifying the cell from damaging ROS, these compounds can stimulate ROS production, triggering an apoptotic cascade in the cell. In this …

Examination Of Sleep Disturbance, Anxiety Sensitivity, And Depression In An Undergraduate Sample, Dasha Grace

Honors Theses

Sleep contributes to overall well-being, mental health, and daily functioning. Sleep disturbances negatively affect psychological, physiological, and biological processing, and the quality of sleep is similarly affected by these processes. The effects of sleep disturbance call for a greater understanding of depression and anxiety sensitivity among college students. Studies have found that sleep disturbance affects nearly 90% of the college student population. The aims of the current study were to examine: 1) types and rates of sleep disturbance among a sample of college students, 2) associations between sleep disturbance, AS, and depression symptoms, and 3) AS and depression symptoms by …

Differential Effects Of Verbal And Written Disclosure On Perceptions Of A Child Who Stutters, Peyton Mcknight

Honors Theses

This study measured perceptions of a 12-year-old boy who stutters, relative to perceived speech skills and personal characteristics, as a function of seven potential stuttering disclosure conditions, featuring either a personal verbal disclosure, written disclosure, or no disclosure, delivered by various authors (i.e., self/child, mother, teacher). 641 participants college-aged adults were randomly assigned to one of seven stuttering disclosure groups: no disclosure control, verbal self-disclosure, written self-disclosure, verbal mother disclosure, written mother disclosure, verbal teacher disclosure, or written teacher disclosure. Participants in the control group viewed a brief video of a 12-year-old male who stutters reciting a short passage. Participants …

Examining The Institution Of Public Health: The Case Of The James C. Kennedy Wellness Center, Hannah Hoang

Honors Theses

This thesis aims to function as an analysis of the James C. Kennedy Center and the impact capacity the Center has on community health and wellness in Tallahatchie County, Mississippi. Poor health is a global problem that is especially prominent in Tallahatchie County which ranked 81st out of 82 Mississippi counties in 2012. This thesis used institutional theory to explain the relationship between the Center and public health. Through interviews and data analysis, a broad evaluation was performed on the Center’s programs and community impact. Results showed that the Kennedy Center has made a large impact in improving the health …

The Raphe-Hippocampal Tract And Its Age Differences: Diffusion Tensor Imaging And Probabilistic Tractography Study, Ashley Sekul

Honors Theses

The raphe-hippocampal tract links the raphe nuclei to the hippocampus and is responsible for the production of the neurotransmitter serotonin. The hippocampus is key in regulating emotional and stress responses. This study utilized diffusion tensor imaging which uses Functional Magnetic Resonance Imaging to provide scans of the brain for analyzing differences in the raphe-hippocampal tract as one ages. In this specific study, 491 samples were visually analyzed to gather data about the fractional anisotropy of the raphe nuclei in both male and female brains ranging from 6 to 85 years old. Through the ranking of images, some were discarded, and …

Examining The Possibilities Of Telehealth In Tallahatchie County, Taran Carrasco

Honors Theses

This thesis aims to analyze Tallahatchie County and determine the feasibility of establishing a telehealth program in the county. Telehealth is an evolving aspect in the medical field that incorporates technology with healthcare. This thesis used sociotechnical theory to explain how the feasibility of telehealth could be made more likely as the technology is used over time.Through interviewing UMMC telehealth directors, Tallahatchie Wellness center workers, and citizens of Charleston, this study aims to gauge professional and personal opinions on how feasible it would be to implement telehealth into the Charleston community, as well as how positively telehealth would be accepted …

Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier

Honors Theses

Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …

Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, Monica Stacy

Honors Theses

Reports in the media by celebrities have sparked an interest in a phenomenon being called “selfie-wrist,” in which smartphone users develop symptoms traditionally associated with carpal tunnel syndrome (CTS). There has been no research to date which investigates the claims of “selfie wrist.” The primary aim of this study was to address the validity of “selfie wrist” claims. The secondary aim of this study was to further investigate the effects of texting on musculoskeletal health, taking into account the differences between texting one-handed versus two-handed, and the effect of using a grip device while texting.

The experiment consisted of an …

Improving Diabetes Self-Management Developing A Patient Decision Aid To Improve Patient Education, Morgan Baker

Honors Theses

Type 2 diabetes is a complex disease that affects a large population of people. It is imperative that efforts are made to develop more effective and inclusive treatment strategies for patients with this condition. A promising approach being studied is the utilization of community pharmacists to individualize and implement diabetes self-management training and education. The objective of this study is to develop a preliminary version of a patient decision aid (PDA) designed to evaluate patient knowledge and behavior towards diabetes self-management for use in the community pharmacy setting. The study design used to achieve this objective was a cross-sectional survey …

Investigating The Link Between Executive Function And Creativity In School Aged Children, Katherine Crenshaw

Honors Theses

The primary purpose of this research was to examine links between executive function (i.e., EF or conscious control) and creativity in school aged children. To accomplish this, participants completed measurements of creativity (i.e., Alternative Uses) and EF (i.e., the Backwards Digit Span to test working memory, the Delay of Gratification task to test inhibition). I also examined whether a creative manipulation (i.e., free coloring or coloring task-relevant materials) would impact EF performance in the Dimensional Card Change Sort (DCCS) focused on cognitive flexibility. While I did not find evidence for a relationship between my measures of EF and creativity, I …

Healthcare Workers' Perceptions Of Different Types Of Interpreters In The Gulf South, Meg Hayslip

Honors Theses

Medical interpreters are important in the healthcare community. Many studies have focused on the consequences of not having an interpreter. A variety of problems can be caused by "language brokering" when no interpreter is available. These studies will be discussed in the literature review. Many states have requirements to become certified as an interpreter, and the selection criteria is what makes a person a “good” interpreter. Previous research, such as that by Chan et al., has shown how different styles of interpreting can affect the quality of health care. This study focuses on how healthcare personnel and their patients view …

Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly

Honors Theses

Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration …

The Effects Of Written Stuttering Disclosure On Young Adult's Perceptions Of Children Who Stutter, Ashlee Manahan

Honors Theses

Abstract:

Purpose: This study measured between-group differences in perceived speech skills and personality characters of a 12-year-old male child who stutters (CWS) as a function of a written factual stuttering disclosure statement, delivered by a male CWS, his “mother”, and his “teacher”.

Methods: Four-hundred twenty-four college aged adults were randomly assigned to one of four groups. The groups included three experimental groups (i.e. written self-disclosure, written mother-disclosure, written teacher disclosure) and a control group (no written disclosure). Participants in the control condition viewed a brief video of a 12-year-old male who stutters. In the experimental conditions, participants viewed a brief …

Baseline Health Assessment Of A Rural Delta Community, Sydney Mitchell

Honors Theses

The Lower Mississippi Delta is characterized by poverty, chronic health issues, health disparities, and food insecurity. The rural Delta communities are primarily African American, experiencing disproportionately higher rates of poverty, job loss, and chronic health problems. Historically, chronic health issues have persisted in these areas over time, including obesity, hypertension, and diabetes, which have only seemed to increase in this region. The food environment in this rural region tends to assist in the creation of the largely obesogenic population which, in turn, contributes to the increased prevalence of diabetes and hypertension and a lower quality of life. Many residents in …

Characterization Of A Plasmid-Based Dna Vaccine For Simian Immunodeficiency Virus, Priya Sanipara

Honors Theses

Described as one of the world’s worst pandemics, HIV (Human Immunodeficiency Virus) infects millions of people each year and is the cause for AIDS (Acquired Immunodeficiency Syndrome). Despite the development of vaccines for numerous infectious diseases such as polio, small pox, and influenza, a vaccine for HIV remains elusive due to the virus’s high mutation rate and ability to evade the immune system. HIV causes depletion of CD4+ lymphocytes, resulting in a weakened immune system. However, the development of a plasmid-based DNA vaccine approach may help revolutionize vaccine development for HIV due to its ability to confer cellular and humoral …

Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque

Honors Theses

Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …

Correlation Of Inflammation In Arthritis With The Myelination In The Brain, Anna Spears

Honors Theses

This study was conducted to investigate whether the influence of arthritis has an effect on the cerebral white matter. The project was performed at the South Oxford Campus, where diffusion tensor imaging (DTI) data was obtained from the Nathan Kline Institute-Rockland Sample (NKI- RS). Image processing was conducted using Functional Magnetic Resonance Imaging of Brain Software Library in which we obtained raw data to formulate Apparent Diffusion Coefficient (ADC), Axial Diffusivity (AD), Radial Diffusivity (RD), and Fractional Anisotropy. A one way Analysis of Covariance (ANCOVA) was performed to determine the significant difference between the history of arthritis on each of …

Detection And Characterization Of Delta-9-Tetrahydrocannabinol And Novel Synthetic Cannabinoid Metabolites Using Human Liver Microsomes, Seema Murugan

Honors Theses

Marijuana and synthetic cannabinoids are the most commonly used and trafficked illicit drug. ∆⁹-tetrahydrocannabinol (THC) is the primary active compound in marijuana. Synthetic cannabinoids were created as a method to study the effects of cannabinoids on the endocannabinoid system, which consists of endogenous cannabinoids, cannabinoid receptors, and the synthetic and degrading enzymes responsible for the synthesis and degradation of endocannabinoids. Cannabinoids activate the same receptors as endocannabinoids. Synthetic cannabinoids gained popularity as recreational drugs due to their ability to avoid detection. Synthetic cannabinoids have been found to have a greater binding affinity to the cannabinoid CB₁ receptor …

An Evaluation Of The Treatment Of Asthma In The State Of Mississippi Using Hedis Quality Control Measures, Kyle Kantor

Honors Theses

Introduction: Asthma is an inflammatory condition of the lungs that can have significant impacts on a patient’s quality of life. Asthma attacks can be very uncomfortable and even deadly in some cases. The objective of this study is to evaluate the treatment of asthma in the state of Mississippi and to describe the disparities between demographics to help healthcare providers identify patients who might be at risk for poor treatment and help those patients receive quality healthcare. Methods: The data was retrospectively collected from January to December 2014 Mississippi Centers for Medicare and Medicaid Services claims data. This study is …

Dialect Variation Assessment In Speech-Language Pathology, Maliah Wilkinson

Honors Theses

During speech and language assessment, speech language pathologists often utilize tools from sociolinguistics to differentiate between accent and dialect variation from actual speech or language impairments. Perceptual dialectology, is one of these tools. This method of research seeks to investigate the linguistic perspectives of various populations in specific situations (Montgomery, 2012, p. 638). To investigate the perspectives of college students, linguists, and speech-language pathologists surveys analyzed they perceptions of dialects in various settings and their backgrounds. Results from the surveys indicate linguists who participated have educational experience with dialects but not dialect assessments. While speech-language pathologists, have certification that insists …

A Nondestructive Procedure For The Extraction Of Dna From Human Teeth, Mark Reliquias, Ann-Elodie Black

Honors Theses

This research focuses on constructing a procedure that allows for the nondestructive extraction of mtDNA from teeth for forensic DNA analysis. Currently, only a destructive method for extracting DNA from teeth is used in the forensic laboratory to identify an individual. A disadvantage of extracting DNA through a destructive method is the complete or partial loss of the tooth. To extract DNA through a destructive method, the tooth must either be cut horizontally or vertically to access the pulp, or the root ground into a powder to extract DNA from the dentine-cementum. With the destruction of the tooth, additional forensic …

An Educational Audiology Model For Mississippi: Telepractice For Direct Service Provision, Sally Autry

Honors Theses

Hearing loss among school-aged children is becoming increasingly prevalent (CDC, 2019). Having hearing loss in a classroom setting can negatively affect a child’s language development, academic achievement, and social communication. Educational audiology plays a vital role in the academic success of children with hearing loss by providing a full range of audiology services to students, as part of a multidisciplinary team, to facilitate listening, learning, and communication access. By performing specialized assessments, monitoring personal hearing instruments, recommending, fitting, and managing hearing assistive technology, providing support services, and advocating on behalf of students with hearing loss, educational audiologists help to bridge …

Fluorometric Characterization Of A Methylene Blue Derivative Sensitive To Reactive Oxygen Species (Ros), Matthew Weeks

Honors Theses

Methylene blue (MB) has many uses within both microbiology and pharmacology. MB can treat disorders such as methemoglobinemia, malaria, Alzheimer’s disease, and certain forms of cancer. MB is also useful for molecular imaging due to its off-on fluorescent capabilities. MB derivatives with a urea bond at the 10-N position have been cleavable by triggers such as light. However, I was interested in sensitivity to reactive oxygen species (ROS). In this study, I wanted to determine if the MB derivative MB-EA exhibited sensitivity to ROS. MB-EA was exposed to varying concentrations of hydrogen peroxide and MB release was measured. I concluded …

Who Will Do The Good Works?: The Troubling Case Of Secularization And The Failure Of The Welfare State In England And Perú, Gabrielle Anna Schust

Honors Theses

This study examines the contribution and impacts of the social service works done by nuns in the UK in the 1950s and 1960s, and in Perú within the last five years. Specifically, it investigates the relationship between nuns as providers of social services and other providers such as the government. Drawing on existing literature on theories of secularization, and a close examination of the historical evolution of the British and Peruvian welfare state apparatuses, this study contextualizes the social service work of nuns in contemporaneous social, economic, and political circumstances. It finds that the population of nuns is on a …

Synthesis And Characterization Of Pamam-Fatty Acid “Janus-Type” Dendritic Hybrids For Biomedical Applications, Abigail Grace Barker

Honors Theses

Janus dendrimers are amphiphilic macromolecules that have shown promising potential in the biomedical field. Due to their unique structure and properties, these branched block copolymers have the ability to self-assemble into bioinspired spherical nanoaggregates. Because they possess a hydrophobic and hydrophilic moiety, these aggregates show potential as drug delivery systems that can transport both hydrophobic and hydrophilic drugs. However, many of the proposed dendrimer systems suffer from certain weaknesses that hinder their practical usage as clinical treatment options. Some of these shortcomings include specificity, solubility, size, surface charge, and mechanical properties. To combat these problems, we synthesized and characterized a …

From Zero To One Hundred: Assessing Discomfort In Different Cuff Widths Following Use Of Blood Flow Restriction, Raksha Chatakondi

Honors Theses

Purpose: To examine the impact of cuff width, pressure, and sex on the perceptual response to blood flow restriction through a series of six experiments. Methods: Experiment One (n=50), Experiment Two (n=105), and Experiment Three (n=105) took place in the upper body, and Experiment Four (n=100), Experiment Five (n=100), and Experiment Six (n=100) took place in the lower body. Perceptual discomfort was measured following each condition. Results: Results are expressed as mean (+ SD). In Experiment One, there were no differences in discomfort. In Experiment Two, the wide cuff resulted in more discomfort [43 (20) AU] compared to the narrow …

Assessment Of Orofacial Myofunctional Profiles Of Undergraduate Students In The United States, Rachel Yockey

Honors Theses

Background: Previous research indicates a high prevalence of orofacial myofunctional disorders in the general population. It was further reported that orofacial dysfunction may have wide ramifications, such as teeth displacement, articulation errors, swallowing difficulties, middle ear infections, and frequent colds. The purpose of this study was to examine orofacial myofunctional profiles of undergraduate students in the United States.

Method: The English version of the Nordic Orofacial Test-Screening (NOT-S) was used to assess 55 undergraduate university students (age range:18 to 23 years). In addition, each participant completed a standard hearing screening, as well as a hearing history questionnaire.

Results: In our …