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Full-Text Articles in Medicine and Health Sciences
Obesity-Induced Inflammation In Human Mammary Tissue: A Potential Microenvironment Favorable To The Development Of Postmenopausal Breast Cancer Via The Wnt Signaling Pathway, Agathe A. Roubert
Masters Theses
In the United States, over one third of adult women are obese, and one in eight women will be diagnosed with breast cancer in their lifetime. Obesity has been shown to be a risk factor for postmenopausal breast cancer and is associated with increased aggressiveness and poor prognosis regardless of menopausal status. However, the mechanisms involved in the relationship between obesity and breast cancer are still not fully understood. Wnt signaling is often elevated in breast tumors (~60%) and is suspected to play a key role in cancer development. It has been shown that inflammatory cytokines, such as TNF-α, IL-1β, …
The Effects Of Menopausal Vasomotor Symptoms And Changes In Anthropometry On Breast Cancer Etiology, Victoria Hart
The Effects Of Menopausal Vasomotor Symptoms And Changes In Anthropometry On Breast Cancer Etiology, Victoria Hart
Doctoral Dissertations
One of the strongest predictors of breast cancer risk is mammographic density; however, incomplete understanding of the mechanisms relating density to risk has limited its use as a marker for breast cancer susceptibility. Hormone fluctuations during the menopausal transition may influence declines in mammographic density and may also trigger the onset of menopausal vasomotor symptoms (VMS), which have been associated with lower breast cancer risk. The effects of hormone changes on density, VMS, and breast cancer risk are complicated by external factors such as changing body mass and hormone therapy use during the menopausal transition. We evaluated the association between …